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CFLAR — NFKB1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kreuz et al., Mol Cell Biol 2001
:
We found that cFLIP can be upregulated in some cell lines under critical involvement of the NF-kappaB pathway, but
NF-kappaB activation was clearly not
sufficient for
cFLIP induction in all cell lines ... These data point to an important
role for
NF-kappaB in the regulation of the
cFLIP gene
Okano et al., Lab Invest 2003
(Carcinoma, Hepatocellular...) :
Furthermore, cFLIP over-expression activated nuclear factor (NF)-kappaB and
cFLIP down-regulation
attenuated NF-kappaB activation induced by TNF-alpha or TRAIL
Li et al., Biochem Biophys Res Commun 2003
:
It has been shown that
Casper can either promote or antagonize apoptosis and can
activate the transcription factor
NF-kappaB ... Overexpression of p105 and IkappaBgamma inhibited
Casper induced
NF-kappaB activation and potentiated Casper induced apoptosis
Imamura et al., J Biol Chem 2004
(Inflammation) :
Moreover,
CLARP/FLIP inhibited the FasL- but not the TNF-alpha induced
NF-kappaB activation
Okamoto et al., Genes Cells 2006
:
Taken together, Tax inhibits Fas mediated apoptosis by up-regulating c-FLIP expression in HTLV-I infected cells, and
NF-kappaB activity
plays an essential role in the up-regulation of
c-FLIP
Chang et al., Cell 2006
(Liver Failure, Acute) :
Here we show that TNFalpha mediated JNK activation accelerates turnover of the
NF-kappaB induced antiapoptotic protein
c-FLIP , an inhibitor of caspase-8
Kim et al., Biochem Biophys Res Commun 2006
:
Inhibition of
NF-kappaB activation
resulted in diminished CO-induced
cFLIP expression and increased caspase-8 cleavage from cells treated with TNFalpha/ActD
Golks et al., J Exp Med 2006
(Neoplasms) :
Thus, in addition to inhibiting apoptosis by binding to the death inducing signaling complex, our data demonstrate a novel mechanism by which
c-FLIP controls
NF-kappaB activation and life/death decisions in lymphocytes and DCs
Takahashi et al., Clin Cancer Res 2006
(Chromosome Aberrations...) :
Herein, we ask whether FAS death domain mutations and
NFkappaB mediated overexpression of
cFLIP represent alternative mechanisms for deregulating the extrinsic apoptotic pathway in LBCL subtypes defined by gene expression profiling [ oxidative phosphorylation, B-cell receptor/proliferation, and host response diffuse LBCLs and primary mediastinal LBCLs ]
Eeva et al., Mol Immunol 2007
:
We conclude that the anti-apoptotic signaling of CD40 involves
NF-kappaB mediated induction of
c-FLIP proteins which can interfere with caspase-8 activation
Jiang et al., FASEB J 2006
(Colonic Neoplasms...) :
Stable expression of IKBSR, a known repressor of NF-kappaB activation, and cellular caspase-8-like inhibitory protein (
cFLIP )
inhibited activation of
NF-kappaB in cancer cell media treated muscle cells with an accompanying enhancement of myogenic protein expression and differentiation
Ivanov et al., Exp Cell Res 2006
(Melanoma) :
Furthermore, activation of cJun and suppression of
NF-kappaB by sodium arsenite
resulted in upregulation of the endogenous TRAIL and downregulation of the
cFLIP gene expression ( which encodes one of the main anti-apoptotic proteins in melanomas ) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL induced apoptosis
Kanetaka et al., Exp Cell Res 2008
:
Interferon-alpha
induces transient upregulation of
c-FLIP through
NF-kappaB activation
Benayoun et al., FASEB J 2008
(Muscular Dystrophies, Limb-Girdle) :
NF-kappaB dependent expression of the antiapoptotic factor
c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A
Ueffing et al., Blood 2008
:
In contrast to the general view that
c-FLIP transcription is
controlled predominantly by
nuclear factor-kappaB (NF-kappaB) , induction of c-FLIP ( short ) in T cells was primarily mediated by the calcineurin-nuclear factor of activated T cells ( NFAT ) pathway
Travert et al., J Immunol 2008
(Lymphoma, Follicular) :
Thus, the antiapoptotic signaling of CD40, which interferes with TRAIL induced apoptosis in FL B cells, involves
NF-kappaB mediated induction of
c-FLIP and Bcl-x ( L ) which can respectively interfere with caspase 8 activation or mitochondrial mediated apoptosis
Myung et al., J Pharmacol Exp Ther 2009
:
In accordance,
NFkappaB dependent
cellular FLICE-like inhibitory protein expression level was found to be reduced by 17AAG
Kang et al., Arthritis Res Ther 2009
(Lupus Erythematosus, Systemic...) :
Apigenin also causes apoptosis of hyperactive lupus APCs and T and B cells, probably by inhibiting expression of
NF-kappaB regulated anti-apoptotic molecules, especially COX-2 and
c-FLIP , which are persistently hyperexpressed by lupus immune cells
Braun et al., J Invest Dermatol 2010
(Lymphoma, Large-Cell, Anaplastic...) :
CD30/CD95 crosstalk experiments showed that CD30 ligation leads to
NF-kappaB mediated
c-FLIP upregulation in cALCL cells, which in turn conferred enhanced resistance to CD95 mediated apoptosis
Iyer et al., J Immunol 2011
:
Antioxidant
c-FLIP inhibits Fas ligand induced
NF-kappaB activation in a phosphatidylinositol 3-kinase/Akt dependent manner