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CHEK1 — TP53

Pathways - manually collected, often from reviews:

• BioCarta atm signaling pathway: p53/MDM2 complex (TP53-MDM2) → CHK1 (CHEK1) (modification, collaborate)
• KEGG Cell cycle: CHEK1/CHEK2 → TP53 (protein-protein, phosphorylation)
• KEGG p53 signaling pathway: CHEK1 → TP53 (protein-protein, activation)
• WikiPathways Cell Cycle: CHEK1/CHEK2 → TP53 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TP53 — CHEK1 (physical association, affinity chromatography technology) Tian et al., Neoplasia (New York, N.Y.) 2002*
• IRef Biogrid Interaction: TP53 — CHEK1 (colocalization, imaging technique) Sengupta et al., J Cell Biol 2004*
• IRef Biogrid Interaction: TP53 — CHEK1 (direct interaction, enzymatic study) Goudelock et al., J Biol Chem 2003*
• IRef Biogrid Interaction: TP53 — CHEK1 (direct interaction, enzymatic study) Shieh et al., Genes Dev 2000*
• IRef Hprd Interaction: TP53 — CHEK1 (in vivo) Shieh et al., Genes Dev 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Tian et al., Neoplasia (New York, N.Y.) 2002*, Giaccia et al., Genes Dev 1998*
• IRef Hprd Interaction: TP53 — CHEK1 (in vitro) Shieh et al., Genes Dev 2000*, Xie et al., J Biol Chem 2001, Latonen et al., Oncogene 2001*, Tian et al., Neoplasia (New York, N.Y.) 2002*, Giaccia et al., Genes Dev 1998*
• IRef Intact Interaction: CHEK1 — TP53 (phosphorylation reaction, protein kinase assay) Jin et al., EMBO J 2006*
• IRef Ophid Interaction: CHEK1 — TP53 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005