Gene interactions and pathways from curated databases and text-mining

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AKT3 — CPT2

Text-mined interactions from Literome

Misra et al., Cell Signal 2008 (MAP Kinase Signaling System) : The cAMP activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP stimulated macrophages : Gene silencing of the cAMP activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages ... Concomitantly, 8-CPT-2-O-Me-cAMP mediated upregulation of Akt ( Thr-308 ) protein kinase activity and p-Akt ( Thr-308 ) levels was prevented in plasma membranes and nuclei of the cells
Gates et al., Am J Physiol Gastrointest Liver Physiol 2009 : The Src inhibitors PP2 and SU6656 inhibited basal and CPT-2-Me-cAMP mediated Src and Akt phosphorylation
Li et al., J Huazhong Univ Sci Technolog Med Sci 2011 : Pretreatment of HUVECs with an ERK inhibitor PD98059 or a PI3K inhibitor LY294002 prior to stimulation not only blocked 8CPT-2'OMe-cAMP induced phosphorylation of ERK and Akt , but also significantly reduced cell proliferation and migration
Misra et al., J Cell Biochem 2012 (Prostatic Neoplasms) : 8-CPT-2Me-cAMP caused a two-threefold increase in p-Akt ( S473 ) and Akt ( S473 ) kinase activity in Rictor immunoprecipitates ... Silencing Rictor gene expression by RNAi significantly suppressed 8-CPT-2Me-cAMP induced phosphorylation of Akt at Ser ( 473 ) ... Pretreatment of these cells with the PI 3-Kinase inhibitor LY294002 significantly suppressed 8-CPT-2Me-cAMP dependent p-Akt ( S473 ) and p-Akt ( S473 ) kinase activities, and both effects were rapamycin insensitive