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CSF2 — MAPK9

Text-mined interactions from Literome

Hu et al., Cell Growth Differ 2000 (Leukemia, Myeloid...) : In contrast, treatment of TF-1a cells with granulocyte/macrophage-colony stimulating factor induced only transient activation of MEK and p44/42 MAPK ( 10-20 min ) and an increase ( approximately 50 % ) in cell proliferation, without any change in cellular differentiation
Lehman et al., Am J Physiol Cell Physiol 2001 : Interestingly, peripheral blood neutrophils expressed the highest ( 16-fold ) MAPK activation level in response to GM-CSF
Zubkov et al., Stroke 2001 (Disease Models, Animal...) : ( 6 ) Hemolysate, oxyhemoglobin, and bloody CSF significantly increased MAPK activity in the rabbit basilar artery ... ( 7 ) U0126 abolished the effect of hemolysate, oxyhemoglobin, or bloody CSF on MAPK activation
Suzuki et al., J Immunol 2001 (Inflammation) : In addition, GM-CSF- and TNF induced superoxide release and adherence were inhibited by PD98059 MAPK/ERK kinase inhibitor ) as well as SB203580 ( p38 MAPK inhibitor ), suggesting possible involvement of ERK and p38 MAPK in superoxide release and adherence induced by these cytokines
Hallsworth et al., Am J Respir Crit Care Med 2001 (Asthma...) : In the present study, we examined a requirement for mitogen activated protein ( MAP ) kinase activation for interleukin (IL)-1beta stimulated GM-CSF , RANTES, and eotaxin release
Irusen et al., J Allergy Clin Immunol 2002 (Asthma) : Activation of p38 MAPK by IL-2 and IL-4, as shown by means of phosphorylation of activated transcription factor 2, resulted in GR phosphorylation and reduced dexamethasone repression of LPS stimulated GM-CSF release
Cárcamo et al., Blood 2002 : Vitamin C suppressed GM-CSF dependent phosphorylation of the signal transducer and activator of transcription 5 ( Stat-5 ) and mitogen activated protein ( MAP ) kinase ( Erk1 and Erk2 ) in a dose dependent manner as was phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in HL-60 cells
Wong et al., Am J Respir Cell Mol Biol 2003 : IL-3, IL-5, and GM-CSF could enhance p38 MAPK and NF-kappaB activity and induce ICAM-1, CD11b, and CD18 expressions on eosinophils
Kutsuna et al., Am J Physiol Cell Physiol 2004 : These findings suggest that TNF, GM-CSF , and G-CSF induce actin depolymerization and morphological changes through activation of ERK and/or p38 MAPK and that cytokine induced actin reorganization may be partly responsible for the inhibitory effect of these cytokines on neutrophil chemotaxis
Pei et al., Acta Pharmacol Sin 2003 (MAP Kinase Signaling System) : And mitogen activated protein kinase ( MAPK ) inhibitor, PD 98059 ( 10 micromol/L ), completely blocked IGF-1, GM-CSF , and EGF induced expression of Cbfa1 promoter activity ( P < 0.01 )
Tortorella et al., Mech Ageing Dev 2004 : No changes in GM-CSF induced p38 MAPK phosphorylation were observed
Baumann et al., Leuk Res 2005 : Although both GM-CSF and G-CSF activate p42/44 MAPK in neutrophil progenitors, the ability of G-CSF to cause MAPK activation is lost in mature neutrophils, while GM-CSF exposure still causes activation
Senokuchi et al., J Biol Chem 2005 : Statins did not inhibit Ox-LDL induced GM-CSF production, but inhibited GM-CSF induced p38 MAPK activation ... GM-CSF induced p38 MAPK activation and macrophage proliferation was partially inhibited by overexpression of dominant negative Ras and completely by that of RhoA ... GM-CSF induced p38 MAPK phosphorylation was also inhibited by farnesyl transferase inhibitor or geranylgeranyl transferase inhibitor, and farnesyl pyrophosphate and geranylgeranyl pyrophosphate prevented the suppression of GM-CSF induced p38 MAPK phosphorylation by statins ... In conclusion, statins inhibited GM-CSF induced Ras- or RhoA-p38 MAPK signal cascades, thereby suppressing Ox-LDL induced macrophage proliferation
Ip et al., Immunopharmacol Immunotoxicol 2005 : IL-3, IL-5, and GM-CSF could augment the phosphorylation of p38 MAPK and nucleus translocation of NF-kappaB in eosinophils
Smith et al., Br J Pharmacol 2006 (Pneumonia) : p38 MAPK may regulate cytokine production, therefore, the effect of two p38 MAPK inhibitors, SB239063 and SD-282, on the release of TNF-alpha, GM-CSF and IL-8 from human macrophages was investigated
Chen et al., Zhonghua Nan Ke Xue 2006 (Neoplasms, Hormone-Dependent...) : [ Role of MAPK signal transduction pathway phosphorylation induced by granulocyte-macrophage-colony stimulating factor in the proliferation of hormone independent prostate cancer ]
ten Hove et al., Mol Immunol 2007 : Differential regulation of TNFalpha and GM-CSF induced activation of P38 MAPK in neutrophils and eosinophils
Zaheer et al., J Neurochem 2007 (Encephalitis...) : Inhibition of p38 MAPK or NF-kappaB by specific inhibitors prevented GM-CSF production
Uemura et al., Int J Lab Hematol 2009 (Leukemia, Neutrophilic, Chronic) : We also showed that stat3 and mitogen activated protein kinase activation by G-CSF or GM-CSF in the patient 's neutrophils were significantly lower than those in healthy donor neutrophils
Ha et al., FEBS J 2008 (Arthritis, Rheumatoid) : These results imply that GM-CSF signaling activates mitogen activated protein kinase , followed by the upregulation of MLN51 and FLICE-inhibitory protein, resulting in fibroblast-like synoviocyte hyperplasia in rheumatoid arthritis
Liu et al., Invest Ophthalmol Vis Sci 2008 : Poly ( I:C ) -induced expression of IL-6, IL-8, G-CSF , MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II
Zhou et al., PloS one 2009 (MAP Kinase Signaling System) : This identifies a novel role for MEK/MAPK mediated cytostatic factor (CSF) activity during meiosis in membrane protein trafficking in mouse oocytes, and shows for the first time that selective retrieval of membrane proteins is a feature of meiosis in mammalian oocytes
Ishii et al., J Biol Chem 2009 : AICAR suppressed GM-CSF induced macrophage proliferation without suppressing p38 MAPK/Akt signaling
Knobloch et al., Thorax 2009 : ET-1- and TNFalpha induced GM-CSF expression were both reduced by bosentan as well as by specific inhibition of either ET ( A ) R, ET ( B ) R, p38 ( MAPK ) or ERK-1/-2
Dohgu et al., Journal of neuroinflammation 2011 : These results show that p44/42 and p38 MAPK signaling pathways mediate the LPS enhanced release of IL-6 and GM-CSF
Chatterjee et al., J Biol Chem 2013 (Cholera...) : These vesicles induced expression of proinflammatory cytokines such as IL-8 and GM-CSF and chemokines such as CCL2, CCL20, and thymic stromal lymphopoietin in epithelial cells through activation of MAPK and NF-?B pathways in NOD1 dependent manner
Reece et al., Immunology 2013 : We show for the first time that LPS stimulation of CB progenitor cells results in autocrine activation of p38 MAPK dependent GM-CSF secretion facilitating Eo/B differentiation ex vivo
Büscher et al., Mol Cell Biol 1995 : Expression of a dominant negative ras mutant reduced, but did not abolish, CSF-1 mediated stimulation of MEK and MAPK
Jiao et al., Exp Hematol 1997 : Despite the heightened growth responses of the motheaten macrophages to GM-CSF, there were no marked differences between motheaten macrophages and normal controls in GM-CSF induced phosphorylation of GM-CSFR beta, Jak2, STAT5 and MAPK , indicating that these molecules are not major HCP substrates in GM-CSF signaling
Hiraguri et al., J Allergy Clin Immunol 1997 : Granulocyte-macrophage colony stimulating factor and IL-5 activate mitogen activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils
Villunger et al., Br J Haematol 1998 (Multiple Myeloma...) : The expressed cytokine receptor alpha-subunit was able to constitute a functional signalling complex with the ubiquitously expressed GM-CSFRbeta subunit, as demonstrated by the fact that GM-CSF induced the p21-ras/mitogen activated protein kinase ( MAPK ) signalling cascade in malignant plasma cell lines
McLeish et al., J Leukoc Biol 1998 : The phosphatidylinositol 3-kinase inhibitor, wortmannin, attenuated stimulation of ERKs and p38 MAPK by GM-CSF , but not TNF-alpha ... Our data suggest that TNF-alpha and GM-CSF activate ERKs and p38 MAPK by different signal transduction pathways
Suzuki et al., Blood 1999 : MEK inhibitor ( PD98059 ) reduced tyrosine phosphorylation of ERK, but not p38 MAPK , induced by G-CSF, GM-CSF , or TNF ... GM-CSF- or TNF induced superoxide ( O2- ) release was inhibited by p38 MAPK inhibitor ( SB203580 ) in a dose dependent manner, suggesting the possible involvement of p38 MAPK in GM-CSF- or TNF induced O2- release
Aoshiba et al., J Immunol 1999 : Granulocyte-macrophage CSF and anti-Fas Ab, which altered the rate of apoptosis, did not affect phosphorylation and activation of p38-MAPK