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Chaqour et al., J Mol Cell Cardiol 1999 : These data strongly suggest that stretch induced PAF receptor gene expression is mediated by NF-kappaB binding to the PAF receptor gene promoter and that protein kinase C activation is among the molecular features of NF-kappaB activation and translocation into the nucleus in mechanically stretched cells
Sakaguchi et al., Hepatology 1999 (Drug-Induced Liver Injury...) : Both LPS and PAF activate nuclear factor-kappa B (NF-kappaB) , a key transcription factor for tumor necrosis factor-alpha (TNF-alpha) and cytokine induced neutrophil chemoattractant ( CINC ) ... Based on these results, we propose that PAF contributes to continuous CINC up-regulation and NF-kappaB activation via accumulation and activation of neutrophils, and thereby is involved in LPS induced liver injury in regenerating rat livers
Wang et al., Br J Pharmacol 2001 : Pretreatment of rats with pyrrolidine dithiocarbamate ( PDTC ) suppresses LPS-, but not PAF- , induced NF-kappaB and C/EBP binding activity, and significantly increases the C/EBP-delta subunit in LPS- or PAF induced C/EBP complex
Tsuyuki et al., Biochim Biophys Acta 2002 : As we had found previously that thapsigargin, an endomembrane Ca2+-ATPase inhibitor, induces production of intracellular platelet activating factor (PAF) [ Br. J. Pharmacol. 116 ( 1995 ) 2141 ], we decided to investigate the possible roles of intracellular PAF in nuclear factor (NF)-kappaB activation of thapsigargin stimulated rat peritoneal macrophages
De Plaen et al., Immunology 2002 : However, whether LPS and PAF directly activate NF-kappaB in enterocytes remains controversial ... In this study, we first investigated the effect of LPS and PAF on NF-kappaB activation in IEC-6 ( a non transformed rat small intestinal crypt cell line ) cells, by electrophoresis mobility shift assay and supershift, and found that LPS, but not PAF , activates NF-kappaB mostly as p50-p65 heterodimers
Seo et al., Eur J Immunol 2004 (Neovascularization, Pathologic) : These data indicate that PAF induced NF-kappaB activation is a common upstream pathway leading to the production of crucial macrophage derived angiogenic factors
Venkatesha et al., J Biol Chem 2004 : Interestingly, PAF induced significantly higher NF-kappaB and nuclear factor of activated T cells ( NFAT ) -luciferase activity as well as CCL2 production in cells expressing DeltaST-PAFR than those expressing PAFR ... Furthermore, a Ca2+/calcineurin inhibitor completely inhibited PAF induced NFAT activation and CCL2 production but not NF-kappaB activation
Seo et al., Cancer Res 2004 (Adenocarcinoma...) : Taken together, these results suggest that estrogen induces the production of angiogenic factors via a mechanism involving PAF mediated NF-kappaB activation
Hidalgo et al., Br J Pharmacol 2005 : 2. In the present study, we analyzed the effect of andrographolide on the activation of NF-kappaB induced by platelet activating factor (PAF) and N-formyl-methionyl-leucyl-phenylalanine ( fMLP ) in HL-60 cells differentiated to neutrophils ... 4. Andrographolide ( 5 and 50 microM ) inhibited the NF-kappaB-luciferase activity induced by PAF
Ko et al., FEBS Lett 2005 : PAF increased mRNA expression, protein synthesis, and MMP-9 activity in ECV304 cells, in a NF-kappaB dependent manner ... PAF increased MMP-9 promoter activity in ECV304, which was inhibited by WEB2107, and NF-kappaB inhibitors
Ko et al., FEBS Lett 2005 : Furthermore, PAF induced NF-kappaB activation was blocked by selective inhibitors of Ca ( 2+ ), PI3K, or extracellular signal regulated kinase ( ERK )
Heon Seo et al., Cancer Res 2006 (Melanoma, Experimental) : These data indicate that PAF induces up-regulation of antiapoptotic factors in a NF-kappaB dependent manner in a melanoma cell line, therefore suggesting that PAF may diminish the cytotoxic effect of chemotherapeutic agents
Choi et al., Immunology 2007 (Candidiasis...) : In studying the mechanisms underlying the susceptibility of the kidney to candidal infection, we previously reported that the reduced production of cytokines [ i.e. tumour necrosis factor-alpha (TNF-alpha) ] via platelet activating factor (PAF) induced activation of nuclear factor-kappaB (NF-kappaB) renders the organ susceptible to the fungal burden ... PAF induced early activation of NF-kappaB and TNF-alpha mRNA expression were both observed in the kidneys of mice infected with non-pathogenic strains of C. albicans, but not in mice infected with pathogenic strains ... Impairment of PAF mediated early NF-kappaB activation following infection with pathogenic C. albicans was associated with the prevention of activation of the enzyme cytosolic phospholipase A ( 2 ) ( cPLA(2) ) as well as the upstream pathway of cPLA(2), p38 mitogen activated protein kinase
Ying-fang et al., Indian J Med Res 2007 : At this optimum concentration, PAF significantly increased the cell proliferation index ( PI ) and the PCNA positive rate in the ASMCs, as well as NF-kappaB DNA- binding activity
Ibe et al., Cell Prolif 2008 (Anoxia) : SMC-PV proliferated more than SMC-PA and PAF plus hypoxia augmented NF-kappaB protein expression
Maitra et al., Journal of inflammation (London, England) 2009 : Our data demonstrate that WFA blocks PAF induced activation of NFkappaB as determined using reporter assays, IL-8 measurements and high-content fluorescent imaging of NFkappaB subunit p65 translocation
Borthakur et al., Inflamm Bowel Dis 2010 : siRNA silencing of Bcl10 was used to examine its role in PAF induced NF-kappaB activation and IL-8 production ... Bcl10 was required for PAF induced I kappaB alpha phosphorylation, NF-kappaB activation, and IL-8 production in NCM460, a cell line derived from normal human colon, and Caco-2, a transformed human intestinal cell line
Tan et al., Biochim Biophys Acta 1994 : Our results indicate that both PAF and TNF stimulate the expression of NF-kappa B p50/p105 in vivo
Ye et al., Adv Exp Med Biol 1996 : Potential significance of PAF induced NF-kappa B activation is discussed
Im et al., Eur J Immunol 1997 : The activation of NF-kappa B by PAF preceded the LPS mediated TNF-alpha gene expression ... These data suggest that PAF , which is released immediately or shortly after LPS injection, induces the expression of TNF-alpha through the activation of NF-kappa B
De Plaen et al., Biochim Biophys Acta 1998 : We found that : ( a ) NF-kappaB is constitutively active in rat small intestine ; ( b ) PAF at a dose below that causing shock and bowel necrosis enhances DNA binding activity of NF-kappaB within 30 min after injection ; activated NF-kappaB contains predominantly p50 subunits ; ( c ) immunohistochemistry showed that PAF induced translocation of p50 into the nucleus of cells of the lamina propria, as well as of the epithelium ; and ( d ) the effect of PAF is abrogated by neutrophil depletion, suggesting a role of neutrophils in NF-kappaB activation