Kojima et al., Biomaterials 2006
(Carcinoma, Hepatocellular) :
Hepatic functions of the attached cells, such as albumin secretion, induction of CYP1A1 and CYP1A2 genes, and metabolic capacity of CYP1A1/2 as measured by the ethoxyresorufin O-deethylase assay, were not significantly changed
Choi et al., Biopharm Drug Dispos 2007
:
It has been reported that plasma albumin concentrations were significantly lower in cancer patients than those in the healthy volunteers, and the expression and mRNA level of hepatic microsomal cytochrome P450 (CYP) 1A2 increased in mutant Nagase analbuminemic rats (NARs)
Wattanachai et al., Drug Metab Dispos 2012
:
Effect of albumin on human liver microsomal and recombinant CYP1A2 activities : impact on in vitro-in vivo extrapolation of drug clearance