Gene interactions and pathways from curated databases and text-mining

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DIO2 — INS

Text-mined interactions from Literome

Brabant et al., FASEB J 2005 (Insulin Resistance...) : In diet induced obesity ( DIO ) , hepatic insulin signaling is impaired but the link between leptin and insulin signaling pathways is only incompletely defined ... The aim of the present study was to evaluate the effects of DIO on leptin and insulin cross signaling in the liver
Levin et al., Am J Physiol Regul Integr Comp Physiol 2005 (Disease Models, Animal...) : The DIO phenotype and exaggerated insulin response to oral glucose in the nonobese, chow fed state persisted in the F6 generation
Ropelle et al., J Physiol 2006 (Insulin Resistance...) : Diet induced obesity ( DIO ) increased the expression and activity of the protein tyrosine phosphatase 1B (PTP1B) and attenuated insulin signalling in gastrocnemius muscle of rats, a phenomenon which was reversed by a single session of exercise
Begg et al., Endocrinology 2013 (Anorexia...) : However, after a peripheral bolus injection of insulin, cerebrospinal fluid insulin increased in Con and DIO-rev rats but not in the DIO group