◀ Back to EIF4G1
EIF4G1 — EIF4H
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
EIF4G1
→
EIF4H
(reaction)
Pestova et al., Nature 2000, Asano et al., Genes Dev 2000, Chakrabarti et al., J Biol Chem 1991, Peterson et al., J Biol Chem 1979, Trachsel et al., J Mol Biol 1977, Benne et al., J Biol Chem 1978
-
Reactome Reaction:
EIF4G1
→
EIF4H
(indirect_complex)
Trachsel et al., J Mol Biol 1977, Benne et al., J Biol Chem 1978, Grifo et al., J Biol Chem 1983, Pestova et al., Nature 1998, Imataka et al., EMBO J 1998
Text-mined interactions from Literome
Pilipenko et al., Genes Dev 2000
:
Reconstitution of initiation using fully fractionated translation components indicated that
48S complex formation on both IRESs
requires eIF2, eIF3, eIF4A, eIF4B,
eIF4F , and the pyrimidine tract binding protein (PTB) but that the FMDV IRES additionally requires ITAF ( 45 ), also known as murine proliferation associated protein ( Mpp1 ), a proliferation dependent protein that is not expressed in murine brain cells
Jeske et al., EMBO J 2011
:
The initiation factor
eIF4G is specifically displaced, and
48S pre-initiation complex formation is
inhibited