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ETS1 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Redlich et al., Arthritis Rheum 2001
(Arthritis, Rheumatoid...) :
The
effects of interleukin-1 (IL-1) or
tumor necrosis factor alpha (TNFalpha) on
Ets-1 expression and activation ( DNA binding ) in cultured synovial fibroblasts were analyzed by Western blotting and DNA gel shift assay, respectively ... Both IL-1 and
TNFalpha induced pronounced up-regulation of
Ets-1 in synovial fibroblasts
Goetze et al., Atherosclerosis 2001
(Arteriosclerosis) :
TNFalpha induces expression of transcription factors c-fos, Egr-1, and
Ets-1 in vascular lesions through extracellular signal regulated kinases 1/2 ... In cultured rat aortic VSMC,
TNFalpha ( 100 U/ml )
stimulated a rapid and transient expression of
Ets-1 , Egr-1 and c-fos with a maximal induction 1 h after stimulation ... In cultured RAW 264.7 mouse macrophages,
TNFalpha similarly
induced the expression of
Ets-1 , Egr-1, and c-fos
Nakamura et al., J Immunol 2004
(Asthma) :
Furthermore, treatment of fibroblasts with Ets-1 antisense oligonucleotides down-regulated
TNF-alpha induced
Ets-1 , MMP-9, and, to a lesser extent, tenascin protein expression or activity
Lee et al., Infect Immun 2005
:
Our data indicate that the increased
Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are
responsible , at least in part, for the increased
TNF-alpha and NOS2 production observed in these infected cells and that ERK1/2 is required for Ets/Elk activity and full TNF-alpha production
Sangiovanni et al., PloS one 2013
:
In vitro,
ETs inhibited
TNF-a induced NF-kB driven transcription ( IC50 : 0.67-1.73 µg/mL ) and reduced TNF-a induced NF-kB nuclear translocation ( 57 % -67 % at 2 µg/mL )
von der Ahe et al., Nucleic Acids Res 1993
:
The -76/-56 region contains three direct repeats of the ets-core sequence GGAA that are important for specific high basal activity,
TNF alpha
repression and trans-activation by expression of
Ets-1 and 2