Gene interactions and pathways from curated databases and text-mining

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FAS — RELA

Text-mined interactions from Literome

Chan et al., Mol Cell Biol 1999 : Activation dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment
Hsing et al., J Immunol 1999 : Surprisingly, up-regulation of Fas , CD23, and ICAM-1 was partially independent, and up-regulation of LFA-1 was completely independent , of CD40 induced NF-kappaB activation
Dudley et al., Eur J Immunol 1999 : NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes
Lee et al., J Immunol 2000 : STAT-1alpha and NF-kappaB activation are involved in IFN-gamma- or TNF-alpha mediated Fas up-regulation in microglia, respectively
Li-Weber et al., Eur J Immunol 2000 : We show that both elements bind to NF-kappaB and SP-1 transcription factors and NF-kappaB is involved in transactivation of the CD95L promoter upon T cell activation
Trauzold et al., Oncogene 2001 (Adenocarcinoma...) : We report here that the stimulation of the CD95- and TRAIL-resistant human pancreatic adenocarcinoma cell line PancTuI with an agonistic anti-CD95 antibody or TRAIL resulted in activation of protein kinase C and NF-kappaB ... Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished activation of NF-kappaB by anti-CD95 and TRAIL
Chakraborty et al., Cancer Res 2001 (Neoplasms, Hormone-Dependent...) : Neither Fas pathway activation alone nor inhibition of NF-kappaB activity with IkappaB-super repressor was sufficient to induce apoptosis of prostate cancer cells
Afford et al., FASEB J 2001 (Liver Cirrhosis, Biliary) : CD40 activation induced, Fas dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells
Russo et al., Am J Physiol Cell Physiol 2002 : Differential requirement for NF-kappaB inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas
Scheller et al., Eur J Immunol 2002 (Inflammation...) : Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of CD95 was mediated by MEK/ERK, p38 and NF-kappaB signaling pathways
Qin et al., J Immunol 2002 (Leukemia, Myeloid, Acute) : Fas resistance of leukemic eosinophils is due to activation of NF-kappa B by Fas ligation ... Although activation of NF-kappaB by ligation of Fas ( CD95/Apo-1 ), a member of the TNFR family, has been observed in a few studies, Fas mediated NF-kappaB activation has not previously been shown to protect cells from apoptosis ... We examined the Fas induced NF-kappaB activation and its antiapoptotic effects in a leukemic eosinophil cell line, AML14.3D10, an AML14 subline resistant to Fas mediated apoptosis
Malewicz et al., J Biol Chem 2003 : In addition, NF kappa B downstream of TNFR was required for up-regulation of Fas expression by endogenous TNF secreted in response to TCR stimulation
Okano et al., Oncol Rep 2003 (Carcinoma, Hepatocellular) : Fas stimulation activates NF-kappaB in SK-Hep1 hepatocellular carcinoma cells ... However, the role of Fas in induction of NF-kappaB activation in HCC cells is not well understood ... Fas stimulation induced NF-kappaB activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines, but not in HLE cells
El-Guendy et al., Mol Cell Biol 2003 : Interestingly, a 59-amino-acid core that included NLS2 but not the C-terminal leucine zipper domain was necessary and sufficient to induce Fas pathway activation, inhibition of NF-kappaB activity, and apoptosis
Lagunoff et al., Int Rev Immunol 2003 : Virally encoded genes inhibit the activation of caspase-8 by the TNF receptor and Fas ; activate NF-kappaB to increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53, thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Watabe et al., J Biol Chem 2004 : Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells ... Our findings demonstrate that NFkappaB inhibition is sufficient to induce apoptosis and that Fas activation plays a role in NFkappaB inhibition induced apoptosis in MCF-7 cells
Fujita et al., Oral Oncol 2004 (Carcinoma, Squamous Cell...) : Our results suggest that NF-kappaB activated at early stages in the okadaic acid treated SCC-25 cells stimulated the promoter activity of Fas receptor in the cells leading to the apoptotic death of these cells
Meli et al., Ann N Y Acad Sci 2003 (Lymphoma, T-Cell) : Overall, these data suggest that NF-kappaB inhibition may restore the Fas-pathway in Fas-resistant NF-kappaB overexpressing tumors
Suzuki et al., Infect Immun 2004 : However, endogenous tumor necrosis factor alpha- and Fas induced signals, extracellular signal regulated kinase kinase/mitogen activated protein kinases and I-kappa B alpha/nuclear factor-kappa B (NF-kappa B) were not required for caspase-3 dependent apoptosis
Suhara et al., Hypertension 2004 (Arteriosclerosis) : Hcy increased NF-kappaB DNA binding activity, and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene inhibited Hcy induced Fas expression
Wurzer et al., J Biol Chem 2004 : NF-kappaB dependent induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and Fas/FasL is crucial for efficient influenza virus propagation
Sinha et al., J Biol Chem 2004 (Insulin Resistance) : We conclude that FAs induce insulin resistance and activates NFkappaB in L6 cells
Kreuz et al., J Cell Biol 2004 : NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP ... Remarkably, the enzymatic activity of the latter was dispensable for Fas induced NFkappaB signaling pointing to a scaffolding related function of caspase-8 in nonapoptotic Fas signaling
Wiener et al., Exp Cell Res 2004 (Carcinoma, Non-Small-Cell Lung...) : Synergistic induction of the Fas ( CD95) ligand promoter by Max and NFkappaB in human non-small lung cancer cells
Legembre et al., Cell cycle (Georgetown, Tex.) 2004 (Neoplasms) : In fact overexpression of apoptosis inhibitors such as Bcl-2 or c-FLIPL in these cells results in decreased activation of NF-kappaB through CD95
Legembre et al., EMBO Rep 2004 : Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds
Starace et al., FASEB J 2005 : We studied the role of the transcription factor NF-kappaB and of MAPKs in regulating Fas expression
Wu et al., J Bone Miner Res 2005 (Bone Resorption) : The involvement of NF-kappaB in the regulation of Fas by RANKL was analyzed by luciferase assay and EMSA
Vega et al., Oncogene 2005 (Burkitt Lymphoma...) : The involvement of NF-kappaB and YY1 in the regulation of Fas expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor ( ER ) mutant ) and by silencing YY1 with YY1 siRNA, respectively
Le Clorennec et al., Blood 2006 (Cell Transformation, Viral...) : Epstein-Barr virus ( EBV ) induces CD95 expression and the CD95 gene ( FAS ) is regulated by NF-kappaB , STAT1, and/or p53
Maksimow et al., J Leukoc Biol 2006 : Fas costimulation of naive CD4 T cells is controlled by NF-kappaB signaling and caspase activity
Packham et al., Cell Death Differ 1997 : Fas activates NF-kappaB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha ... Surprisingly, Fas induced signaling also triggered the activation of NF-kappaB in T cells, yet the kinetics of NF-kappaB induction by Fas was markedly delayed
Lee et al., EMBO J 2006 : In contrast, CD95 ligand stimulation of cells unable to internalize CD95 results in activation of proliferative Erk and NF-kappaB signaling pathways
Wong et al., Clin Immunol 2006 : Fas ( CD95 ) ligation inhibits activation of NF-kappa B by targeting p65-Rel A in a caspase dependent manner
Wang et al., Asian J Androl 2006 : NF-kappa B is activated by increased FasL/Fas in CORT induced Leydig cell apoptosis
Wosik et al., J Neurol Sci 2007 : TNFR1 ligation induces NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8, as well as adhesion molecules ICAM-1 and VCAM-1, while Fas and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2, p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs
Pan et al., Int J Oncol 2007 (Bile Duct Neoplasms...) : The inverse activities of Fas and FasL promoter in tumor cells are regulated by NF-kappaB , which inhibits Fas expression and increases FasL expression through binding to their respective promoters
Motadi et al., Int Immunopharmacol 2007 (Carcinoma...) : Of the several molecular targets, those receiving attention are p53 gene replacement, Bcl-2 downregulation, apoptosis by induced by TNF, the FAS/CD95 receptor system and TRAIL, and inhibition of NF-kappaB
Le Clorennec et al., J Virol 2008 : Therefore, our results are in agreement with a model where LMP1 dependent NF-kappaB activation induces Fas overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB, revealing an ambivalent function of LMP1 in cell survival and programmed cell death
Neumann et al., Molecular systems biology 2010 : We established an integrated kinetic mathematical model for CD95 mediated apoptotic and NF-kappaB signaling
Ehrenschwender et al., Cell Death Differ 2010 (Neoplasm Invasiveness) : In mutant PIK3CA expressing cells, tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and CD95L stimulated nuclear factor kappaB (NFkappaB) activation, invasion, and transition to an amoeboid-like morphology
Schulze-Osthoff et al., EMBO J 1994 : Whereas transcription factor NF-kappa B was readily activated by TNF, activation was not induced by triggering APO-1/Fas
Rensing-Ehl et al., J Inflamm 1995 : With regard to their cytoplasmic homology region, we investigated whether Fas like the TNF-R activates nuclear factor kappa B (NF-kappa B) , using human SV80 fibroblasts transfected with the cDNA encoding human Fas
Ravi et al., Cancer Res 1998 : We demonstrate that ligation of CD95 ( Fas/APO1 ), a potent apoptotic stimulus in lymphocytes, results in repression of NF-kappaB activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50
Bauer et al., J Biol Chem 1998 : Moreover, inhibition of NF-kappaB activity by a transdominant IkappaB mutant attenuated CD95L expression
Grammer et al., J Immunol 1998 (Burkitt Lymphoma) : By contrast, induction of apoptosis, activation of NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54, MHC class II, and CD95 were unaffected by the TRAF3 dominant negative
Giardina et al., Biochim Biophys Acta 1999 (Colorectal Neoplasms) : Cell death does correlate with alterations in NF-kappa B activity : the NSAIDs, butyrate and H2O2 enhance c-Rel complex formation by TNF-alpha and provide an overall enhancement of NF-kappa B activation by Fas