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CTNNB1 — FBXW11

Pathways - manually collected, often from reviews:

• KEGG Wnt signaling pathway: BTRC/FBXW11 → CTNNB1 (protein-protein, ubiquination)
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin (CTNNB1) → beta catenin/beta TrCP1 complex (CTNNB1-FBXW11) (modification, collaborate)
  Soriano et al., J Cell Biol 2001
  Evidence: assay, other species
• NCI Pathway Database Presenilin action in Notch and Wnt signaling: beta catenin/beta TrCP1 complex (CTNNB1-FBXW11) → Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B) (modification, collaborate)
  Soriano et al., J Cell Biol 2001
  Evidence: assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — FBXW11 (physical association, affinity chromatography technology) Gao et al., Mol Cell 2011
• IRef Biogrid Interaction: CTNNB1 — FBXW11 (physical association, affinity chromatography technology) Watanabe et al., Proc Natl Acad Sci U S A 2005*
• IRef Biogrid Interaction: CTNNB1 — FBXW11 (physical association, affinity chromatography technology) Fuchs et al., Oncogene 1999
• IRef Intact Interaction: Complex of GSK3B-AXIN1-CTNNB1-FBXW11-GSK3B-AXIN1-CTNNB1-FBXW11 (association, anti bait coimmunoprecipitation) Li et al., Cell 2012
• IRef Intact Interaction: FBXW11 — CTNNB1 (physical association, anti bait coimmunoprecipitation) Li et al., Cell 2012
• IRef Intact Interaction: FBXW11 — CTNNB1 (physical association, anti tag coimmunoprecipitation) Li et al., Cell 2012

Text-mined interactions from Literome

Spiegelman et al., Oncogene 2002 : In the NIH3T3 cells, which express HOS, but not betaTrCP, Wnt/beta-catenin signaling leads to inhibition of HOS promoter activity and NF-kappaB-driven transcription as well as to stabilization of beta-catenin
Katoh et al., Cancer Biol Ther 2006 : Because GSK3beta dependent phosphorylation of beta-catenin and SNAIL leads to FBXW1 ( betaTRCP ) -mediated ubiquitination and degradation, GSK3beta downregulation results in the stabilization and the nuclear accumulation of beta-catenin and SNAIL