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FGF2 — IGF1R
Pathways - manually collected, often from reviews:
-
KEGG Melanoma:
EGF/FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD
→
EGFR/FGFR1/IGF1R/MET/PDGFRA/PDGFRB
(protein-protein, activation)
-
WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Text-mined interactions from Literome
Du et al., Endocrinology 1996
:
Nuclear run-on assays indicated that angiotensin II and
fibroblast growth factor stimulated
IGF-I receptor gene transcription by 2.1- and 2.5-fold, respectively ... Thus, angiotensin II and
fibroblast growth factor transcriptionally
regulate the
IGF-I receptor gene by protein kinase C-independent and -dependent pathways, respectively
Scheidegger et al., J Biol Chem 1999
:
Distinct and common pathways in the
regulation of
insulin-like growth factor-1 receptor gene expression by angiotensin II and
basic fibroblast growth factor ... Our findings indicate that Ang II and
bFGF significantly
increased IGF-1R promoter activity up to 7- and 3-fold, respectively ... In addition, co-transfection of dominant negative Ras, Raf, and MEK1 or pretreatment with the MEK inhibitor PD 98059 dose-dependently decreased both the Ang II- and
bFGF induced increase in
IGF-1R transcription and protein expression, suggesting that the Ras-Raf-mitogen activated protein kinase kinase pathway is required for both growth factors