Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
FOXO4
→
MAPK8
(directlyIncreases, FOXO4 Activity)
Vogt et al., Cell cycle (Georgetown, Tex.) 2005* Evidence: JNK then phosphorylates cytoplasmic FOXO proteins at the C-terminal sites that are distinct from the Akt phosphorylation sites. JNK-induced phosphorylation initiates nuclear import of FOXO proteins and activation of their transcriptional regulatory potential.