Gene interactions and pathways from curated databases and text-mining

◀ Back to WNT16

FZD4 — WNT16

Pathways - manually collected, often from reviews:

  • KEGG Wnt signaling pathway: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  • KEGG Melanogenesis: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  • KEGG Pathways in cancer: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  • KEGG Basal cell carcinoma: WNT1/WNT10A/WNT10B/WNT11/WNT16/WNT2/WNT2B/WNT3/WNT3A/WNT4/WNT5A/WNT5B/WNT6/WNT7A/WNT7B/WNT8A/WNT8B/WNT9A/WNT9B → FZD1/FZD10/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9 (protein-protein, activation)
  • WikiPathways ESC Pluripotency Pathways: WNT3/WNT5B/WNT7A/WNT5A/WNT16/WNT10A/WNT7B/WNT2/WNT9B/WNT3A/WNT11/WNT4/WNT1/WNT6/WNT10B/WNT2B → Complex of 12 proteins (activation)
  • WikiPathways Wnt Signaling Pathway and Pluripotency: WNT9B/WNT4/WNT7B/WNT10B/WNT5B/WNT2B/WNT3A/WNT16/WNT7A/WNT2/WNT11/WNT1/WNT6/WNT5A/WNT10A/WNT3 → FZD8/FZD7/FZD5/FZD1/FZD6/FZD3/FZD2/FZD10/FZD9/FZD4 (activation)
  • WikiPathways Wnt Signaling in Kidney Disease: WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B → FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3 (activation)
  • WikiPathways Wnt Signaling in Kidney Disease: WNT1/WNT10A/WNT10B/WNT7A/WNT16/WNT6/WNT5A/WNT2B/WNT11/WNT4/WNT3A/WNT5B/WNT9B/WNT2/WNT3/WNT7B → LRP5/LRP6/FZD1/FZD8/FZD4/FZD2/FZD7/FZD9/FZD5/FZD6/FZD3 (activation)
  • WikiPathways Association Between Physico-Chemical Features and Toxicity Associated Pathways: WNT16 → FZD1/FZD2/FZD3/FZD4/FZD5/FZD6/FZD7/FZD8/FZD9/FZD10 (activation)

Text-mined interactions from Literome

Swain et al., Cell communication and signaling : CCS 2005 : It is not known how FZD4S can activate Wnt/beta-catenin signaling and what biological role this molecule plays in vivo
Tickenbrock et al., Int J Oncol 2008 (Leukemia, Myeloid, Acute) : Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4
Junge et al., Cell 2009 : TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt induced FZD4/beta-catenin signaling
Gupta et al., Cancer Res 2010 (Prostatic Neoplasms) : FZD4 as a mediator of ERG oncogene induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells ... Taken together, our results provide mechanistic insights to ERG oncogenesis in prostate cancer, involving activation of WNT signaling through FZD4 , leading to cancer promoting phenotypic effects, including EMT and loss of cell adhesion
Zhang et al., J Biol Chem 2011 (Osteoporosis...) : In HEK293 transfection studies, C45Y, Y58C, and C204R mutants did not bind to Norrin and failed to transduce FZD4 mediated Wnt/ß-catenin signaling
Mössinger et al., EMBO Rep 2012 (Wnt Signaling Pathway) : Itch directly associates with and ubiquitinates PI4KIIa, and both proteins colocalize on endosomes containing Wnt activated frizzled 4 (Fz4) receptor
Deng et al., J Cell Sci 2013 (Wnt Signaling Pathway) : Norrin, the Norrie disease gene product, is also capable of activating Wnt signaling mediated by the Frizzled4 receptor and serves as a BMP antagonist