Gene interactions and pathways from curated databases and text-mining

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GBP6 — IFNG

Text-mined interactions from Literome

Saunders et al., J Invest Dermatol 1999 (Carcinoma, Squamous Cell...) : In order to understand the proximate events regulating interferon-gamma action we studied the relationship between interferon-gamma mediated induction of a cytoplasmic guanylate binding protein and the expression of growth and differentiation marker genes in normal and transformed keratinocytes
Kunzelmann et al., Methods Enzymol 2005 : The synthesis of human guanylate binding protein 1 ( hGBP1 ) is induced by interferon-gamma and its biological function is related to antiviral activity and regulation of proliferation
Hulst et al., Arch Virol 2008 (Rotavirus Infections...) : Furthermore, up-regulation was observed for IFN-gamma induced guanylate binding protein 2, a protein that effectively inhibited VSV and EMCV replication in vitro ( Arch Virol 150 : 1213-1220, 2005 )
Abdullah et al., J Mol Biol 2009 : Unlike other GTPases, interferon-gamma induced human guanylate binding protein-1 has the ability to hydrolyze GTP to both GDP and GMP, with GMP being the major product of the reaction
Lipnik et al., Mol Med 2010 (Adenocarcinoma...) : Interferon gamma induced human guanylate binding protein 1 inhibits mammary tumor growth in mice
Messmer-Blust et al., Mol Biol Cell 2010 (Melanoma) : The interferon-gamma induced murine guanylate binding protein-2 inhibits rac activation during cell spreading on fibronectin and after platelet derived growth factor treatment : role for phosphatidylinositol 3-kinase ... Expression of the IFN-gamma induced GTPase murine guanylate binding protein-2 ( mGBP-2 ) can phenocopy this inhibition and small interfering RNA knockdown of mGBP-2 prevents IFN-gamma mediated inhibition of cell spreading
Nicolet et al., J Immunol 1994 : We have investigated the regulation of an activation associated guanylate binding protein gene ( mGBP-1/mag-1 ) in murine macrophage cell lines in response to the cytokine IFN-gamma