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GCH1 — TNF
Text-mined interactions from Literome
Yao et al., Zhonghua Wai Ke Za Zhi 2000
(Shock, Septic) :
Treatment with pentoxifylline significantly decreased plasma biopterin and
TNF levels at 2 to 8 hours after endotoxin challenge ( P < 0.05, P < 0.01 ), and
inhibited GTP-CHI activities in the liver, lung, and myocardial tissues ( P < 0.05 )
Huang et al., Circ Res 2005
:
Conversely, overexpression of Jak2 effectively substituted for IFN-gamma in supporting
TNF-alpha mediated
GTPCH I induction ... However, Stat1 activation with oncostatin M failed to support
TNF-alpha mediated
GTPCH I induction because of concomitant Stat3 activation