Gene interactions and pathways from curated databases and text-mining

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GCH1 — TNF

Text-mined interactions from Literome

Yao et al., Zhonghua Wai Ke Za Zhi 2000 (Shock, Septic) : Treatment with pentoxifylline significantly decreased plasma biopterin and TNF levels at 2 to 8 hours after endotoxin challenge ( P < 0.05, P < 0.01 ), and inhibited GTP-CHI activities in the liver, lung, and myocardial tissues ( P < 0.05 )
Huang et al., Circ Res 2005 : Conversely, overexpression of Jak2 effectively substituted for IFN-gamma in supporting TNF-alpha mediated GTPCH I induction ... However, Stat1 activation with oncostatin M failed to support TNF-alpha mediated GTPCH I induction because of concomitant Stat3 activation