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GDNF — IRF6
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McNaught et al., Neurosci Lett 2000
:
Glutathione depletion or complex I inhibition, but not
LPS induced activation,
impaired dopamine stimulated
GDNF release
Simi et al., J Neurochem 2005
:
We found that ( 1 ) LPS induced c-fos mRNA levels were sensitive to p38 mitogen activated protein kinase ( MAPK ) inhibitors but not to mitogen-activated/extracellular signal regulated kinase ( ERK ) or calcium-calmodulin dependent kinase inhibitors, ( 2 ) LPS activated both serum response element ( SRE ) and cyclic AMP/calcium response element ( CRE ) -driven luciferase reporters in transient transfection assays, ( 3 )
LPS induced the phosphorylation of Elk1 CRE binding protein ( CREB )
/activated transcription factor-1 (ATF-1) and the activation of GAL4-Elk1 and GAL4-CREB chimeric proteins, and ( 4 ) mutation of both SRE and CRE elements was necessary and sufficient to completely abolish LPS induction of a rat c-fos proximal promoter-luciferase reporter
Tanaka et al., Neurosci Lett 2008
:
NF-kappaB independent signaling pathway is responsible for
LPS induced
GDNF gene expression in primary rat glial cultures ... MG132, a blocker of nuclear factor kappaB (NF-kappaB) activation, did not apparently affect
LPS induced
GDNF gene expression, whereas it attenuated the up-regulation of iNOS genes via Toll-like receptor (TLR) 4 ... Of the several MAP kinase inhibitors tested, a JNK-specific inhibitor blocked
LPS induced
GDNF transcription in primary cultures of microglia, but not of astrocytes ... These results suggest that LPS up-regulates GDNF transcription through an NF-kappaB independent pathway, and that JNK is responsible for
LPS stimulated
GDNF transcription in primary cultures of microglia
Krifka et al., Biomaterials 2012
:
LPS induced expression of activated transcription factors c-Jun,
ATF-2 , ATF-3 and phospho-Elk1 was decreased in cells co-treated with TEGDMA
Appel et al., Neuroreport 1997
(Inflammation) :
We have examined the
effects of
lipopolysaccharide (LPS) and inflammatory cytokines on the expression of
GDNF by mouse astrocytes and by C6 glial cells
Pan et al., J Biol Chem 1998
:
These data indicate that the kappaB sites and the variant
ATF/CRE are
required for TNF-alpha or
LPS to optimally induce expression of the murine P-selectin gene