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GNA12 — PLD4

Text-mined interactions from Literome

Rümenapp et al., J Biol Chem 2001 : PLD stimulation by the M ( 3 ) mAChR was enhanced by the overexpression of Galpha(12) and Galpha(13), whereas the overexpression of Galpha ( q ) strongly increased PLC activity without affecting PLD activity
Huang et al., Am J Physiol Cell Physiol 2004 : The Ca2+ sensing receptor couples to Galpha12/13 to activate phospholipase D in Madin-Darby canine kidney cells ... These findings demonstrate that the CaR couples to Galpha12/13 to regulate PLD via a Rho dependent mechanism and does so independently of Galphai and Galphaq
Ziembicki et al., American journal of physiology. Renal physiology 2005 : Mechanical force activated phospholipase D is mediated by Galpha12/13-Rho and calmodulin dependent kinase in renal epithelial cells