Gene interactions and pathways from curated databases and text-mining

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EPO — GRB2

Pathways - manually collected, often from reviews:

  • BioCarta epo signaling pathway: EPO/EPO R/EPO R complex (EPOR-EPO) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 1994 : We recently reported that interleukin-3, Steel factor, and erythropoietin all induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cell lines
Damen et al., Blood 1993 : Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein
Hanazono et al., Acta Haematol 1996 : Furthermore, we have shown that the proto-oncogene c-cbl product (c-Cbl) is also tyrosine phosphorylated by stimulation with GM-CSF or Epo and is constitutively associated with the SH3 domain of Grb2/Ash in UT-7