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HRG — MAPK15

Text-mined interactions from Literome

Campiglio et al., J Cell Biochem 1999 (Ovarian Neoplasms) : Both EGF and HRG induced activation of mitogen activated protein kinase ( MAPK ), but the time course of MAPK activation differed depending on the hetero-dimers induced
Xiong et al., Cancer Res 2001 (Breast Neoplasms...) : These results show that HRG can activate p38 MAPK to enhance VEGF transcription via an upstream HRG response element, leading to increased VEGF secretion and angiogenic response in breast cancer cells
Lee et al., Cancer Res 2001 (Breast Neoplasms) : p85-sErbB3 inhibits HRG induced phosphorylation of ErbB2, ErbB3, and ErbB4 in breast carcinoma derived cell lines and can also block HRG stimulated activation of mitogen activated protein kinase , Akt, and association of ErbB3 with the phosphatidylinositol 3'-kinase p85 regulatory subunit
Atlas et al., Oncogene 2003 (Breast Neoplasms) : HRG/M was unable to autophosphorylate the erbB receptors and did not affect the level of MAPK phosphorylation
Cantó et al., J Biol Chem 2004 : HRG also stimulated the activity of p70S6K, p38MAPK , and p42/p44MAPK and inhibition of p42/p44MAPK partially repressed HRG action on glucose uptake
Sakai et al., Cancer Sci 2007 (Carcinoma, Non-Small-Cell Lung...) : Pertuzumab blocked HRG-alpha stimulated phosphorylation of HER3, mitogen activated protein kinase ( MAPK ), and Akt
Yonezawa et al., Digestion 2009 (Adenocarcinoma...) : HRG also activated p85 PI-3K, Akt, ERK1/2, and p38 MAPK
Cho et al., Mol Med Report 2008 : The present results suggest that Akt and MAPK mediate HRG-ß1 signaling to MMP-9