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HSP90AB1 — IL6

Text-mined interactions from Literome

Ripley et al., Immunology 1999 : Recent studies have shown that the cytokine IL-6 activates hsp 90 gene expression via specific transcription factors that include STAT-3 ( signal transducer and activator of transcription 3 )
Ripley et al., J Autoimmun 2001 (Lupus Erythematosus, Systemic) : These results support a model in which elevated levels of IL-6 in SLE patients induce elevated levels of hsp90 protein which in turn results in the production of autoantibodies to this protein
Stephanou et al., Biochem J 1997 : Hence the induction of hsp90 protein accumulation by IL-6 is likely to be dependent on the enhanced activity of the hsp90 beta gene promoter produced by increased levels of NF-IL-6 and/or NF-IL-6 beta
Stephanou et al., Biochem J 1998 : The nuclear factor interleukin-6 ( NF-IL6 ) and signal transducer and activator of transcription-3 ( STAT-3 ) signalling pathways co-operate to mediate the activation of the hsp90beta gene by interleukin-6 but have opposite effects on its inducibility by heat shock ... The levels of the 90 kDa heat-shock protein ( hsp90 ) and the activity of the hsp90beta gene promoter are increased in response to treatment by interleukin (IL)-6