Gene interactions and pathways from curated databases and text-mining

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CASP4 — HTRA3

Text-mined interactions from Literome

Tillman et al., Cancer Res 2003 (Colonic Neoplasms) : In RKO, rottlerin induced the release of cytochrome c, HtrA2/Omi , Smac/DIABLO, and AIF from the mitochondria, potentiated in combination with TRAIL, with concomitant caspase activation and down-regulation of XIAP
Zhang et al., Sci China C Life Sci 2008 : The release of Cyt c, HtrA2 and Smac from mitochondria did not occur via the same mechanism, the release of Cyt c and HtrA2 was caspase independent and the release of Smac was caspase dependent