Gene interactions and pathways from curated databases and text-mining

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CASP4 — IAPP

Text-mined interactions from Literome

Rumora et al., Biol Chem 2002 (Insulinoma...) : Human amylin induces significant activation of caspase-3 and strong and sustained phosphorylation of stress activated protein kinases, c-Jun N-terminal kinase (JNK) and p38, that precedes cell death
Zhang et al., J Biol Chem 2003 (Insulinoma) : Human amylin, as well as truncated 8-37human amylin, evoked sequential activation of caspases-8 and -3, and apoptosis, whereas non-beta-sheet forming and non-fibrillogenic homologs, such as [ 25,28,29triprolyl ] human amylin, did not, implying that the beta-sheet conformer is required for human amylin induced caspase activation