Gene interactions and pathways from curated databases and text-mining

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ICAM1 — MAPK12

Text-mined interactions from Literome

Etienne-Manneville et al., J Immunol 1999 : We show that ICAM-1 binding induces cAMP accumulation and activation of the mitogen activated protein kinase extracellular signal regulated kinase
Park et al., J Leukoc Biol 2002 : Thus, the results of this work suggest that p43 should induce cell-cell adhesion via the PI3-K/ERK- and p38 MAPK dependent up-regulation of ICAM-1
Yan et al., Zhonghua Shao Shang Za Zhi 2001 : [ The role of p38 MAPK in LPS induced ICAM-1 expression on endothelial cell ] ... To study the role of p38 mitogen activated protein kinase ( MAPK ) in lipopolysaccharide (LPS) induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) on human umbilical vein endothelial cell ( HUVEC )
Yan et al., Shock 2002 (Shock, Septic) : Role of p38 MAPK in ICAM-1 expression of vascular endothelial cells induced by lipopolysaccharide ... In this study, the potential role of p38 MAPK in ICAM-1 expression of LPS induced endothelial cells was studied in vitro and in vivo
Lee et al., J Dermatol Sci 2002 (Behcet Syndrome) : Specific MAPK/ERK kinase inhibitor PD98059 inhibited IgM-AECA induced ERK1/2 activities and ICAM-1 expression on HDMEC at a concentration of 60 microM
Wong et al., Am J Respir Cell Mol Biol 2003 : IL-3, IL-5, and GM-CSF could enhance p38 MAPK and NF-kappaB activity and induce ICAM-1 , CD11b, and CD18 expressions on eosinophils
Wang et al., J Biol Chem 2003 : Previous studies demonstrated that ICAM-1 ligation on human pulmonary microvascular endothelial cells ( ECs ) sequentially induces activation of xanthine oxidase and p38 MAPK
Krüll et al., Infect Immun 2004 : Inhibition of either MAPK had almost no effect on intercellular cell adhesion molecule 1 ( ICAM-1 ) expression
Wu et al., Am J Physiol Heart Circ Physiol 2005 : Inhibitor studies in endothelial cells demonstrated a critical role for PKC in mediating thrombin, TNF-alpha, and LPS induction of ICAM-1 , TF, and u-PA and for p38 MAPK in mediating thrombin, TNF-alpha, and LPS induction of TF
Arnold et al., J Immunol 2005 : The virus induced ICAM-1 up-regulation was dependent on protein kinase C and A, PI3K, and p38 MAPK activity
Miho et al., Cardiovasc Res 2005 : The goal of this study was to determine whether mitogen activated protein ( MAP ) kinases , including extracellular signal regulated kinase 1/2 ( ERK1/2 ), c-Jun N-terminal kinase (JNK), and p38 MAP kinase ( p38 ), mediate thrombin induced ICAM-1 expression in endothelial cells
Ueno et al., Cardiovasc Toxicol 2006 (Atherosclerosis) : Inhibitors of p38 MAPK , PKC, and NF-kappaB suppressed nicotine stimulated expression of ICAM-1 and VCAM-1
Lee et al., Cytokine 2006 (Tooth Migration) : In this study, we investigated the role of mitogen activated protein ( MAP ) kinases in dexamethasone- and TNF-alpha induced IL-8 and ICAM-1 expression in hPDL cells
Traore et al., J Cell Biochem 2007 (Leukemia, Myeloid) : Role of ROS and MAPK in TPA induced ICAM-1 expression in the myeloid ML-1 cell line
Miyazawa et al., J Toxicol Sci 2008 (MAP Kinase Signaling System) : In particular, inhibition of p38 MAPK suppressed CD86, CD54 , and CD40 expression induced by DNCB and CD86 expression induced by NiSO ( 4 ) while inhibition of ERK pathways suppressed CD86, CD54 and CD40 expression induced by DNCB and NiSO ( 4 )
Su et al., Biochim Biophys Acta 2008 (MAP Kinase Signaling System) : We evaluated the role of p38 MAPK , MK2 and HSP27 in regulating the TNF induced expression of ICAM-1 and IL-8 in human lung MVECs ... Inhibition of p38 MAPK reduced ICAM-1 and IL-8 expression without influencing NF-kappaB activation or ICAM-1 and IL-8 mRNA levels ... Our study demonstrates for the first time that MK2 mediates post-transcriptional regulation by p38 MAPK of the TNF induced expression of ICAM-1 and IL-8 in human lung MVECs, and that this regulation by the p38 MAPK/MK2 pathway is dissociated from HSP27 phosphorylation
Ho et al., Immunobiology 2008 (Inflammation...) : Selective inhibitors of p38 MAPK ( SB203580 ), JNK ( SP600125 ) and ERK ( PD98059 ) could suppress TNF-alpha induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha induced VCAM-1 expression
Liu et al., Invest Ophthalmol Vis Sci 2008 : Poly ( I:C ) -induced expression of IL-6, IL-8, G-CSF, MIP-1beta, exotaxin, RANTES, and ICAM-1 was inhibited differentially by the MAPK inhibitors PD98059 and SB203580 and by JNK inhibitor II
Cui et al., Cell Immunol 2009 : p38 MAPK contributes to CD54 expression and the enhancement of phagocytic activity during macrophage development
Zhang et al., Br J Pharmacol 2009 : These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via CRF ( 2 ) receptors and the activation of p38MAPK and NF-kappaB
Krug et al., Hypertension 2010 : MR blockade and extracellular signal regulated kinase 1/2 mitogen activated protein kinase inhibition prevent age associated increases of transforming growth factor-beta, intercellular adhesion molecule 1 , and procollagen 1
Fan et al., Angiology 2010 (HIV Infections) : Furthermore, inhibition of Nef activity by ERK mitogen activated protein kinase ( MAPK ) inhibitor effectively blocked ICAM-1 upregulation, suggesting that ERK MAPK activation is an important initiating event in Nef mediated ICAM-1 expression in Nef expressed cells
Song et al., J Pharmacol Sci 2010 (MAP Kinase Signaling System) : Overall, our results indicated that downregulation of ICAM-1 expression by ruscogenin in HUVECs might be mediated by nuclear factor-kappaB (NF-kappaB), but not by mitogen activated protein kinase ( MAPK ) and Akt signaling pathways
Fong et al., J Cell Physiol 2012 (Bone Neoplasms...) : avß3 and avß5 integrin monoclonal antibody and mitogen activated protein kinase ( MEK ) inhibitors ( PD98059 and U0126 ) inhibited the CCN6 induced increase of the migration and ICAM-1 up-regulation of chondrosarcoma cells
Hsu et al., J Cell Physiol 2011 : Furthermore, resistin increased the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) by HUVECs and these effects were also p38MAPK dependent
Zhang et al., Invest Ophthalmol Vis Sci 2013 (MAP Kinase Signaling System...) : RECs were also transfected with or without NF-?B siRNA or treated with SB202190 ( p38 [ mitogen activated protein kinase ] MAPK inhibitor ) before melphalan treatment to determine the involvement of NF-?B and p38 MAPK in REC apoptosis and ICAM-1 levels ... Although KZ-41 blocked both NF-?B- and p38 MAPK dependent ICAM-1 stimulation ; the p38 MAPK/ICAM-1 pathway appears to be the primary pathway involved in melphalan induced REC apoptosis
Sano et al., Biochem Biophys Res Commun 1998 : Furthermore, ICAM-1 cross linking activated 44- and 42-kDa mitogen activated protein ( MAP ) kinases ( ERK1 and ERK2 ) in endothelial cells, as indicated by the electrophoretic mobility shift of MAP kinases on SDS-polyacrylamide gels ... Furthermore, ICAM-1 cross linking activated 44- and 42-kDa mitogen activated protein ( MAP ) kinases ( ERK1 and ERK2 ) in endothelial cells, as indicated by the electrophoretic mobility shift of MAP kinases on SDS-polyacrylamide gels