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IL1B — TYK2

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12-mediated signaling events: IL1 beta (IL1B) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, activates)
  Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL12-mediated signaling events: IL1 beta (IL1B) → IL12Rbeta1/TYK2 complex (IL12RB1-TYK2) (modification, activates)
  Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
  Evidence: mutant phenotype, assay, physical interaction, other species