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GRAP2 — IL4
Text-mined interactions from Literome
Ling et al., Crit Care Med 2002
:
In contrast to its effects on the janus kinase/STAT pathways,
interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and
p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Huang et al., Cell Mol Immunol 2008
(Calcium Signaling) :
Treatment with Gab2 siRNA significantly decreased Gab2 expression, inhibited the FcepsilonRI mediated mast cell release of beta-hexosaminidase and histamine, reduced the production of
IL-4 and TNF-alpha and
inhibited the phosphorylation of Akt, PKCdelta and
p38 mitogen activated protein kinase ( MAPK )
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Marshall et al., J Immunol 1998
:
IL-4 induced a late ( > 4-h )
increase in
p38 MAPK activity and corresponding activation of its substrate MAPKAPK-2