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ILK — VEGFA

Text-mined interactions from Literome

Kaneko et al., J Cell Sci 2004 : VEGF induced phosphorylation of protein kinase B ( PKB/Akt ), a regulator of cell survival and apoptosis, on serine 473, but not on threonine 308, in an ILK dependent manner
Tan et al., Cancer Cell 2004 (Neovascularization, Pathologic) : In endothelial cells, VEGF stimulates ILK activity, and inhibition of ILK expression or activity results in the inhibition of VEGF mediated endothelial cell migration, capillary formation in vitro, and angiogenesis in vivo ... These data demonstrate an important and essential role of ILK in two key aspects of tumor angiogenesis : VEGF expression by tumor cells and VEGF stimulated blood vessel formation
Wani et al., Oncogene 2011 (Melanoma...) : As STAT3 binds to vascular endothelial growth factor ( VEGF ) promoter, we found that VEGF levels were elevated in ILK overexpressing cells and declined upon transfection of IL-6 small interfering RNA, suggesting that ILK may regulate VEGF expression through IL-6 pathway by activating STAT3