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IGF1 — INSRR
Pathways - manually collected, often from reviews:
-
KEGG Prostate cancer:
EGF/IGF1/INS/PDGFA/PDGFB/PDGFC/PDGFD/TGFA
→
EGFR/ERBB2/FGFR1/FGFR2/IGF1R/INSRR/PDGFRA/PDGFRB
(protein-protein, activation)
Text-mined interactions from Literome
Kovacina et al., J Biol Chem 1995
(Neuroblastoma) :
The intrinsic tyrosine kinase activity of this endogenous
IRR was
activated by the agonist monoclonal antibody to IRR but not by nerve growth factor,
insulin-like growth factor I , or insulin
Jui et al., J Biol Chem 1994
:
However, proinsulin, insulin,
IGF-I , and IGF-II did not
stimulate tyrosine phosphorylation of the
IRR ... However, proinsulin, insulin,
IGF-I , and IGF-II did not
stimulate tyrosine phosphorylation of the
IRR