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IRF1 — IRF8

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRF1 — IRF8 (direct interaction, pull down) Kautz et al., J Biol Chem 2001*
• IRef Biogrid Interaction: IRF1 — IRF8 (direct interaction, two hybrid) Schaper et al., Biochem J 1998*
• IRef Biogrid Interaction: IRF1 — IRF8 (physical association, affinity chromatography technology) Sharf et al., J Biol Chem 1995*
• IRef Hprd Interaction: IRF1 — IRF8 (in vivo) Sharf et al., J Biol Chem 1995*, Schaper et al., Biochem J 1998*
• IRef Hprd Interaction: IRF1 — IRF8 (in vitro) Sharf et al., J Biol Chem 1995*, Schaper et al., Biochem J 1998*
• IRef Innatedb Interaction: IRF1 — IRF8 (unknown, -) Sharf et al., J Biol Chem 1995*
• IRef Innatedb Interaction: IRF1 — IRF8 (unknown, -) Eklund et al., J Immunol 1999*
• IRef Innatedb Interaction: IRF1 — IRF8 (unknown, -) Kautz et al., J Biol Chem 2001*
• IRef Ophid Interaction: IRF1 — IRF8 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Xi et al., Oncogene 1999 (Pancreatic Neoplasms) : Here we report that the human CIITA Type IV promoter IRF-E binds IRF-1 and can be activated by exogenous expression of IRF-1
Marecki et al., J Immunol 2001 : Furthermore, coexpression of IRF-1 and IRF-2 dramatically increased the capacity of both PU.1/IRF-4 and PU.1/ICSBP to induce IL-1beta reporter gene expression in fibroblasts
Xi et al., Mol Immunol 2003 : Off-rate experiments revealed that the IRF-2/IRF-E complex was more stable than the IRF-1/IRF-E complex and that the affinity of IRF-1 for the IRF-E was increased when IRF-1 co-occupied the IRF-E with IRF-2
Guo et al., J Immunol 2005 : IRF-2 constitutively binds to the two ISRE/IRF-E sites at the DRR, while IRF-1 and STAT1 are induced to bind to the two ISRE/IRF-E sites and the ISRE/IRF-E1, respectively, only after IFN-beta treatment
Pan et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010 (Leukemia, Promyelocytic, Acute) : It is concluded that during ATRA induced APL cell differentiation, IRF-1 is first upregulated by ATRA, and then IRF-1 increases the protein levels of IRF-9 and STAT2 with the downregulation of C/EBPalpha
Kondo et al., Hokkaido Igaku Zasshi 1996 (Leukemia...) : Functional analysis showed that IRF-BP inhibited DNA binding and transcriptional activity of IRF-1
Sharf et al., J Biol Chem 1997 : Tyr phosphorylated ICSBP and IRF-2 are detected in expressing cells constitutively, and Tyr phosphorylated IRF-1 is induced by IFN-gamma