Friedland et al., J Cell Sci 2007
:
We report that elevated ( alpha6)beta4 integrin dependent Rac-Pak1 signaling supports resistance to apoptosis in mammary acini by permitting stress dependent activation of the p65 subunit of NF-kappaB through Pak1 ... Thus, mammary tissues can resist apoptotic stimuli by activating NF-kappaB through alpha6beta4 integrin dependent Rac-Pak1 signaling ... Our data emphasize the importance of the extracellular matrix stroma in tissue survival and suggest that alpha6beta4 integrin dependent Rac stimulation of Pak1 could be an important mechanism mediating apoptosis-resistance in some breast tumors
Cruz-Monserrate et al., Neoplasia (New York, N.Y.) 2008
(Adenocarcinoma...) :
Integrin alpha 6 beta 4 promotes migration, invasion through Tiam1 upregulation, and subsequent Rac activation