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Rodríguez et al., Cardiovasc Res 2005 (Hypercholesterolemia) : Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL ... HC-LDL , with high cholesterol ( P < 0.05 ) and reduced tocopherol/cholesterol ratio ( P < 0.05 ), increased significantly VEGF and VEGFR-2 ( p < 0.001 ) in EC, associated with higher O ( 2 ) ( - ) and HIF-1 alpha expression, in comparison with C-LDL and HCV-LDL ... Our data suggest HC-LDL induce endothelial VEGF and VEGFR-2 overexpression at least by increasing oxidative stress, and HIF-1 alpha is one of the signaling mechanisms involved
Usui et al., EMBO Rep 2007 : Here we report that native LDL ( nLDL ) activates vascular endothelial growth factor ( VEGF ) receptor 1 ( VEGFR1 ) but not VEGFR2 through LDLR and is as potent as VEGF in macrophage migration