Li et al., J Gen Virol 2010
(Neuroblastoma) :
Although LAT inhibits caspase 3 activation, the signalling pathway by which LAT inhibits caspase 3 activation was not identified
Jiang et al., J Virol 2011
(Herpes Simplex) :
We report here that ( i ) LAT can interfere with GrB induced apoptosis in cell cultures, ( ii ) LAT can block GrB induced cleavage ( activation ) of caspase-3 both in cell culture and in a cell-free in vitro cell extract assay, and ( iii ) LAT can protect C1300 and Neuro2A cells from cytotoxic CD8 T-cell killing in vitro
Kłossowicz et al., J Immunol Methods 2013
:
Assessment of caspase mediated degradation of linker for activation of T cells (LAT) at a single cell level