Gene interactions and pathways from curated databases and text-mining

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LPA — RELA

Text-mined interactions from Literome

Ediger et al., Eur Respir J 2003 (Cell Transformation, Neoplastic...) : In contrast, nuclear factor (NF)-kappaB was activated by LPA but not EGF and NF-kappaB activation was completely blocked only when Rho was inhibited
Fang et al., J Biol Chem 2004 (Ovarian Neoplasms) : The optimal response of the IL-8 gene promoter to LPA relied on binding sites for NF-kappaB and AP-1, two transcription factors that were strongly activated by LPA in ovarian cancer cell lines
Cummings et al., J Biol Chem 2004 (Inflammation) : Here, we report that protein kinase Cdelta (PKCdelta) mediates LPA induced NF-kappaB transcription and interleukin-8 (IL-8) secretion in HBEpCs ... LPA caused a marked activation of NF-kappaB in HBEpCs as determined by IkappaB phosphorylation and of NF-kappaB nuclear translocation and a strong induction of NF-kappaB promoter mediated luciferase activity ... Furthermore, LPA activated PKCdelta and the LPA mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant negative PKCdelta and rottlerin
Hwang et al., Mol Carcinog 2006 (Neoplasm Invasiveness...) : The LPA induced NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels ... The LPA induced Matrigel invasion and NF-kappaB DNA binding activity were both inhibited by expression of the RhoA inhibitor C3 exoenzyme or dominant negative mutant NF-kappaB inhibitor IkappaBalpha S32/36A ... Each inhibitor blocked LPA induced invasion while PDTC inhibited LPA induced NF-kappaB and invasion to the greatest extent
Sotiriou et al., FASEB J 2006 (Atherosclerosis...) : Through its interaction with Mac-1, Lp(a) induced activation of the proinflammatory transcription factor NFkappaB , as well as the NFkappaB related expression of prothrombotic tissue factor
Klemm et al., Proc Natl Acad Sci U S A 2007 : Here, we identify the adapter proteins Bcl10 and Malt1 as essential mediators of LPA induced NF-kappaB activation ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that Bcl10 and Malt1 are critically required for the degradation of IkappaB-alpha and the subsequent NF-kappaB induction in response to LPA stimulation ... Bcl10 and Malt1 cooperate with PKCs selectively for LPA induced NF-kappaB activation but are dispensable for the activation of the Jnk, p38, Erk MAP kinase, and Akt signaling pathways
Mahanivong et al., Oncogene 2008 (Neoplasm Invasiveness...) : Although constitutively active mutants of PKCalpha ( a cPKC ), PKCtheta ( a novel PKC ( nPKC ) ) and PKCzeta ( an atypical PKC ( aPKC ) ) were all able to activate NF-kappaB and upregulate uPA expression, only dominant negative PKCalpha mutant attenuated LPA induced NF-kappaB activation and uPA upregulation ... These results suggest that PKCalpha, rather than PKC isoforms in other PKC classes, participates in LPA induced NF-kappaB activation and uPA upregulation in ovarian cancer cells
Sebban-Benin et al., Hum Mol Genet 2007 (Incontinentia Pigmenti) : Mutation of all these ubiquitination sites severely impaired NF-kappaB activation induced by stimulation with IL-1, LPS, Nod2/RICK or serum/LPA
Chen et al., J Cell Biochem 2008 (Hypertrophy...) : In addition, LPA stimulated the phosphorylation of Akt and p65 protein and activated NF-kappaB-luciferase expression ... Furthermore, ERK inhibitors ( U0126 and PD98059 ) suppressed LPA stimulated activation of NF-kappaB and p65 phosphorylation whereas wortmannin showed no effect on NF-kappaB activation
Hu et al., Cell Signal 2008 (Burkitt Lymphoma...) : The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression
Arita et al., World J Gastroenterol 2008 (Adenocarcinoma...) : To clarify whether Lysophosphatidic acid (LPA) activates the nuclear translocation of nuclear factor-kappaB (NF-kappaB) in pancreatic cancer ... LPA also caused the nuclear translocation of NF-kappaB ... Staurosporine, a protein kinase C inhibitor, attenuated translocation of NF-kappaB induced by LPA ... These findings suggest that protein kinase C is activated endogenously in Panc-1, and protein kinase C is essential for activating NF-kappaB with cytosolic calcium and that LPA induces the nuclear translocation of NF-kappaB in Panc-1 by mobilizing cytosolic free calcium
Medoff et al., Am J Respir Cell Mol Biol 2009 (Asthma) : We then show that inhibition of CARMA3 activity in airway epithelial cells reduces LPA mediated NF-kappaB activity and the production of TSLP and CCL20
Sun et al., Proc Natl Acad Sci U S A 2008 : Although LPA induced signaling pathways have been intensively investigated, the molecular mechanism by which LPA activates NF-kappaB is not fully defined ... In this work, we found that beta-arrestin 2, but not beta-arrestin 1, is required for LPA induced NF-kappaB activation and interlukin-6 expression
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009 (MAP Kinase Signaling System) : Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated LPA induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion
N'Diaye et al., Life Sci 2009 (Atherosclerosis) : DNA binding activity of NF-kappaB , a well-known molecular effector of TNFalpha, was moreover activated by Lp(a) in a TNFalpha dependent manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction ... In addition, Lp(a) induced binding of NF-kappaB to a NF-kappaB consensus element on CCL1 promoter as assessed by EMSA
Sun et al., Cell Signal 2009 : Although LPA induces NF-kappaB activation by acting on its GPCR receptor, the molecular mechanism of LPA receptor mediated NF-kappaB activation remains to be well defined
Oyesanya et al., Molecular cancer 2010 (Neoplasm Invasiveness) : In contrast, LPA stimulated another prominent transcription factor NF-kappaB via the Gq-PKC pathway in an EGFR independent manner ... In contrast, activation of G12/13, Gq and Gq-elicited NF-kappaB by LPA is independent of such an input
Sun et al., J Biol Chem 2010 : MEKK3 is a central intermediate signaling component in lysophosphatidic acid (LPA) induced activation of the nuclear factor-kappaB (NF-kappaB) ... Furthermore, knockdown of PP2Ac expression enhances LPA induced MEKK3 mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kappaB activation ... These data suggest that PP2A plays an important role in the termination of LPA mediated NF-kappaB activation through dephosphorylating and inactivating MEKK3
Crone et al., Molecular cancer 2012 (Disease Models, Animal...) : Lysophosphatidic acid (LPA) induces NF-kappaB activation via this pathway and over-expression of miR-146a inhibited LPA induced NF-kappaB activation, reduced LPA induced expression of tumor promoting cytokines and growth factors and inhibited monocyte attraction