Gene interactions and pathways from curated databases and text-mining

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LTF — MAPK15

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Grey et al., Mol Endocrinol 2004 : In primary rat osteoblastic cells, the LRP1/2 inhibitor receptor associated protein blocks endocytosis of lactoferrin and abrogates lactoferrin induced p42/44 MAPK signaling and mitogenesis ... Lactoferrin also induces receptor associated protein-sensitive activation of p42/44 MAPK signaling and proliferation in osteoblastic human SaOS-2 cells, which express LRP1 but not LRP2
Hu et al., Neuron 2004 (MAP Kinase Signaling System) : In Aplysia, long-term facilitation (LTF) of sensory neuron synapses requires activation of both protein kinase A (PKA) and mitogen activated protein kinase ( MAPK )
Naot et al., Clin Med Res 2005 (MAP Kinase Signaling System) : Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin
Grey et al., Mol Cell Endocrinol 2006 : Lactoferrin activates p42/44 MAPK signaling, but inhibiting this process does not abrogate its pro-survival actions