Gene interactions and pathways from curated databases and text-mining

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INS — MAP2K4

Text-mined interactions from Literome

Benes et al., Biochem J 1999 : We found that this transcription is regulated in the MIN6 cells in the same range of glucose concentration as in primary islets, and that specific inhibition of mitogen activated protein kinase kinase , the direct activator of ERK, impaired the response of the insulin gene to glucose
Park et al., J Biol Chem 2002 : Insulin inhibited the anisomycin induced stimulation of both endogenous SEK1 and its substrate c-Jun N-terminal kinase (JNK), but not that of the upstream kinase MEKK1, in 293T cells
Ueki et al., J Biol Chem 1994 : Feedback regulation of mitogen activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation
Carel et al., Endocrinology 1996 : Reduced phosphorylation of mitogen activated protein kinase kinase in response to insulin in cells with truncated C-terminal domain of insulin receptor
Kim et al., Biochem J 1997 : Insulin regulation of mitogen activated protein kinase kinase ( MEK ), mitogen activated protein kinase and casein kinase in the cell nucleus : a possible role in the regulation of gene expression
Carlsen et al., Cell Signal 1997 : Insulin stimulated glycogen synthesis was inhibited by the phosphatidylinositol 3-kinase inhibitors wortmannin ( IC50 approximately 40 nM ) and LY 294002 ( IC50 approximately 20 microM ) and the mitogen activated protein kinase kinase inhibitor PD 98059 ( IC50 approximately 40 microM )
Antoine et al., Endocrinology 1998 : Insulin induction of protein kinase C alpha expression is independent of insulin receptor Tyr1162/1163 residues and involves mitogen activated protein kinase kinase 1 and sustained activation of nuclear p44MAPK