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MAP3K7 — TLR4
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TLR4
→
MAP3K7
(reaction)
Kishimoto et al., J Biol Chem 2000, Takaesu et al., Mol Cell 2000, Jiang et al., Mol Cell Biol 2002, Jiang et al., J Biol Chem 2003, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009
-
Reactome Reaction:
TLR4
→
MAP3K7
(indirect_complex)
Kishimoto et al., J Biol Chem 2000, Takaesu et al., Mol Cell 2000, Kanayama et al., Mol Cell 2004, Sato et al., Nat Immunol 2005, Shim et al., Genes Dev 2005, Adhikari et al., Oncogene 2007, Xia et al., Nature 2009
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhou et al., World J Gastroenterol 2008
(Adenocarcinoma...) :
Viable LBG or LBG- ( s ) pretreatment attenuated the expression of
TLR4 ,
inhibited the phosphorylation of
TAK1 and p38MAPK, prevented the activation of NF-kappaB, and consequently blocked IL-8 production
Kar et al., Eur J Immunol 2011
(Inflammation...) :
Analysis of upstream signaling events revealed that
TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase (IRAK)1, TNF receptor associated factor (TRAF)6 and
TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Lin et al., Science signaling 2013
(Inflammation) :
LPS dependent stimulation of
TLR4 in Syk-deficient macrophages
led to enhanced activation of
TAK1 and increased production of proinflammatory cytokines compared to that in wild-type macrophages