Gene interactions and pathways from curated databases and text-mining

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MAPK15 — RAC2

Text-mined interactions from Literome

Mainiero et al., Immunity 2000 (MAP Kinase Signaling System) : Finally, we provide direct evidence that p95 Vav and Rac control the activation of p38 MAPK triggered by beta1 integrins
Versteeg et al., J Biol Chem 2000 : In turn Rac mediates p38 mitogen activated protein ( MAP ) kinase activation and cytoskeletal reorganization, whereas factor VIIa induced p42/p44 MAP kinase stimulation required PI3K enzymatic activity but was not inhibited by dominant negative Rac proteins
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK/ERK activation ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Chen et al., Mol Microbiol 2004 (MAP Kinase Signaling System) : Co-expression of DARas with dominant active Rac ( DARac ) stimulates MAPK activation and restores the wild-type phenotype
Nishida et al., J Biol Chem 2005 : Dominant negative Rac inhibited angiotensin II-stimulated ROS production, JNK activation, and p38 MAPK activation but did not affect ERK activation
Otis et al., Mol Cell Endocrinol 2007 : The increase in cell protein content induced by Ang II entails formation of a cortical actin ring and Rac dependent activation of p42/p44(mapk) and p38 MAPK