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IRF6 — MAPK7

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Chen et al., Mol Pharmacol 1999 : Tyrosine kinase inhibitor, genestein, attenuated the LPS induced activation of both p44/42 MAPK and p38, whereas the PKC inhibitors, Ro 31-8220 and calphostin C, or long-term treatment with 12-O-tetradecanoylphorbol-13-acetate resulted in inhibition of p44/42 MAPK activation, but had only a slight effect on p38 activation, indicating that LPS mediated PKC activation resulted in the activation of p44/42 MAPK ... Thus, activation of p38 but not p44/42 MAPK by LPS resulted in the stimulation of NF-kappaB-specific DNA-protein binding and the subsequent expression of inducible form of NO synthase and NO release in RAW 264.7 macrophages
Nick et al., J Clin Invest 1999 : We investigated the MAPk kinase ( MKK ) that activates p38 MAPk in response to LPS , the p38 MAPk isoforms that are activated as part of this pathway, and the functional responses affected by p38 MAPk activation
Baldassare et al., J Immunol 1999 : LPS stimulated p38 MAPK activity in the RAW264.7 cells was blocked by SB203580, as measured by the inhibition of MAPKAP2 kinase activity, a downstream target of the p38 MAPK
Kraatz et al., J Surg Res 1999 : Endotoxin ( LPS ) activation of macrophages results in phosphorylation of mitogen activated protein kinases ( MAPK ), stress activated protein kinases ( SAPK ), and p38 kinase ... LPS pretreatment inhibits subsequent LPS stimulated MAPK activation and TNF release and both were reversed if macrophages were treated with phorbol myristate acetate ( PMA ) before LPS stimulation ... LPS activated MAPK , SAPK, and p38
Chen et al., Immunology 1999 : LPS activation of nuclear factor-kappa B (NF-kappaB), activator protein-1 (AP-1) and p38 MAPK was also inhibited by SB 203580
Nolan et al., Surgery 1999 : We hypothesize that MAPK activation by LPS signals inhibition of PMN apoptosis
Kovarik et al., Proc Natl Acad Sci U S A 1999 (MAP Kinase Signaling System) : Furthermore, LPS , UV irradiation, and TNF-alpha caused activation of p38 MAPK whereas IFN-gamma did not
Rawlins et al., Int J Immunopharmacol 1999 (MAP Kinase Signaling System) : 5Z-7-oxo-zeaenol was shown to inhibit the phosphorylation and activation of mitogen activated protein kinase ( MAPK ) induced by LPS
Cario et al., J Immunol 2000 : In contrast, LPS did not significantly induce activation of JNK and p38 in CMT93 cells, p38 in T84 cells and MAPK and JNK in HT29 cells
Hippenstiel et al., Blood 2000 : Specific inactivation of RhoA/Cdc42/Rac1 by Clostridium difficile toxin B-10463 ( TcdB-10463 ) reduced LPS induced tyrosine phosphorylation, nuclear factor (NF)-kappaB dependent gene expression, IL-8 messenger RNA, and IL-8 protein accumulation but showed no effect on LPS dependent p38 MAPK activation
Medvedev et al., J Immunol 2000 (MAP Kinase Signaling System) : In this study, the effect of in vitro endotoxin tolerance on LPS induced mitogen activated protein kinase activation, transcription factor induction, and cytokine, chemokine, and Toll-like receptor (TLR) 2 and 4 gene expression, as well as the involvement of TNF and IL-1 signaling pathways in tolerance, were examined
Means et al., J Leukoc Biol 2000 (MAP Kinase Signaling System) : Stimulation of macrophages by lipopolysaccharide (LPS) leads to the rapid activation of MAP kinases ( MAPK ) and the subsequent induction of cytokine gene expression
Shimohashi et al., J Cell Biochem 2000 (Shock, Septic) : LPS can activate both the NF-kappaB signaling pathway and MAPK signal transduction pathways such as JNK and p38 MAPK ... We find that ebselen inhibits LPS induced NF-kappaB nuclear translocalization, and also suppresses the LPS induced phosphorylation of JNK, but not the phosphorylation of p38 MAPK
Kim et al., Brain Res 2000 (Glioma) : LPS transiently increased the phosphorylation of p38-MAPK and CREB
Luo et al., Br J Pharmacol 2000 : Therefore, in this study, we investigated the effect of LPS on mitogen activated protein kinase ( MAPK ) activation associated with potentiation of bradykinin ( BK ) -induced inositol phosphates ( IPs ) accumulation and Ca ( 2+ ) mobilization in canine cultured tracheal smooth muscle cells ( TSMCs ) ... LPS stimulated phosphorylation of p42/p44 MAPK in a time- and concentration dependent manner using a Western blot analysis against a specific phosphorylated form of MAPK antibody ... Furthermore, overexpression of dominant negative mutants, H-Ras-15A and Raf-N4, significantly suppressed p42/p44 MAPK activation induced by LPS and PDGF-BB, indicating that Ras and Raf may be required for activation of these kinases
Bauer et al., Shock 2000 : The effect of adherence on LPS induced activation of MAPK was assessed by western analysis using a dual phosphospecific antibody against p38MAPK, p42,44ERK, and p54SAPK
Dumitru et al., Cell 2000 (MAP Kinase Signaling System...) : LPS stimulation of peritoneal macrophages from these mice did not activate MEK1, ERK1, and ERK2 but did activate JNK, p38 MAPK , and NF-kappaB
Song et al., Shock 2001 (Sepsis) : Twenty-four hours post-CLP, during the late, immune suppressed stage of sepsis, splenic and peritoneal Mphi were harvested, stimulated with lipopolysaccharide (LPS) , and the activation of p38 MAPK assessed
Jones et al., J Leukoc Biol 2001 (MAP Kinase Signaling System) : Stimulation of RAW 264.7 macrophages by LPS , LAM, STF, and PIM rapidly activated nuclear factor (NF)-kappaB, activator protein-1 (AP-1), and mitogen activated protein ( MAP ) kinases
Medvedev et al., J Immunol 2001 : Following LPS exposure, 3E10, 3E10/TLR2, and 3E10/TLR4 cells exhibited comparable decreases in LPS mediated NF-kappaB activation and mitogen activated protein ( MAP ) kinase phosphorylation
Sugiyama et al., J Endotoxin Res 2001 : The LPS induced NF-B and MAPK activation was markedly inhibited by anti-CD14 antibody
Chu et al., J Surg Res 2001 : LPS activated MAPK , which was significantly depressed by G, SB 203580 ( SB ), and PD 98058 ( PD )
Jiang et al., Zhonghua Yi Xue Za Zhi 1999 : [ The role of activation of p38 MAPK induced by LPS in TNF-alpha gene expression ]
Chin et al., Eur J Biochem 2001 : GSNO or LPS inhibited serum induced MAPK activation, and both effects were partially reversed by inhibition of guanylate cyclase or phospholipase A2
van den Blink et al., Mol Med 2001 (Endotoxemia) : We observed that LPS induced a strong but transient phosphorylation and activation of p38 MAPK and p42/p44 MAPK , maximal activity being reached after 1 hr of LPS infusion
Haddad et al., Br J Pharmacol 2002 : In alveolar epithelial cells, LPS induced a time- and dose dependent phosphorylation of MAPK ( p38 )
Utsugi et al., J Leukoc Biol 2002 : LPS induced IL-12 production and p38 mitogen activated protein ( MAP ) kinase activation were enhanced by GSH-OEt but suppressed by DEM. Selective p38 inhibitors showed that p38 promoted GSH-OEt enhanced IL-12 production
Lu et al., Chin J Traumatol 2001 : P38MAPK was activated by LPS ( 100 ng/ml ) with peak activation at 30 minutes
Haddad et al., Biochem Pharmacol 2002 : In addition, LPS up-regulated the phosphorylation of MAPK ( p38 ) in a dose dependent manner ... Whereas NAC blocked the phosphorylation/activation of MAPK ( p38 ), BSO amplified the LPS mediated effect on MAPK ( p38 )
Yan et al., Zhonghua Shao Shang Za Zhi 2001 : [ The role of p38 MAPK in LPS induced ICAM-1 expression on endothelial cell ]
Monick et al., Am J Physiol Lung Cell Mol Physiol 2002 : This study investigates the role of macrophage integrin receptors in the activation of mitogen activated protein ( MAP ) kinases by LPS
Li et al., Endocrinology 2002 : Phosphorylation of p38 MAPK was induced by RANKL, IL-1, TNFalpha, and LPS in osteoclast precursors but not in osteoclasts
Wang et al., J Biol Chem 2002 (MAP Kinase Signaling System) : Pre-exposure of THP-1 cells to BLP suppressed mitogen activated protein kinase phosphorylation and nuclear factor-kappaB activation in response to subsequent BLP and LPS stimulation, which is comparable with that found in LPS tolerized cells, indicating that BLP tolerance and LPS tolerance may share similar intracellular pathways
Bhattacharyya et al., Biochem J 2002 : The stimulation of MAPK signalling in macrophages by LPS of H. pylori amplifies the inflammatory response associated with gastric H. pylori infection and needs to be taken into consideration when developing therapeutics based on these signalling pathways
Kim et al., Nitric Oxide 2002 : In contrast, mercury activated p38 mitogen activated protein kinase ( p38 MAPK ) and additively increased LPS induced p38 MAPK phosphorylation
Khadaroo et al., Surgery 2002 (Reperfusion Injury...) : To discern whether this reduction in LPS stimulated MAPK activation after shock might contribute to reduced IL-10, specific inhibitors were used
Medvedev et al., J Immunol 2002 : Pretreatment of human monocytes with LPS decreased LPS mediated NF-kappaB activation, p38 mitogen activated protein kinase phosphorylation, and TNF-alpha gene expression, documenting the induction of endotoxin tolerance
Nick et al., J Immunol 2002 (Inflammation) : LPS induced activation of p38 MAPK in human neutrophils was inhibited by poststimulation exposure to a p38 MAPK inhibitor ( M39 )
Guo et al., Di Yi Jun Yi Da Xue Xue Bao 2003 : LPS can induce transcription and activation of iNOS gene, and p38 MAPK is involved in the transcription regulation of iNOS gene in HEK 293 cells
Takada et al., J Biol Chem 2003 : LPS activated C-Jun N-terminal kinase, p38MAPK , and extracellular signal regulated kinase in wt cells, but the levels were much higher in p60-/-, p80-/-, and p60-/- p80-/- cells
Woo et al., Brain Res Mol Brain Res 2003 (Encephalitis...) : DbcAMP decreased the LPS induced phosphorylation of p38 MAPK , while it modestly enhanced the ERK activity
Royle et al., J Immunol 2003 : Purified LPS stimulates rapid, transitory mitogen activated protein kinase activation that is inhibited by E5531, whereas bacterial invasion stimulates delayed, prolonged activation, unaffected by E5531
Narayan et al., Immunopharmacol Immunotoxicol 2003 : Peptidomimetic compound was evaluated for its effect on anti-CD3 and recombinant human interleukin-2 ( rhIL-2 ) stimulated lymphocyte proliferation in vitro and lipopolysaccharide (LPS) induced activation of mitogen activated protein kinase ( MAPK, pp42/44 ) in mouse macrophage cells ( RAW 264.7 ) ... However, this peptidomimetic compound did not show any effect on LPS induced MAPK activation
Cuschieri et al., Shock 2003 (MAP Kinase Signaling System...) : LPS stimulation led to mitogen activated protein kinase activation and translocation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB
Comalada et al., Am J Physiol Cell Physiol 2003 : LPS activates PKC and regulates the different mitogen activated protein kinases ( MAPK )
Gee et al., J Biol Chem 2003 : Furthermore, p38 mitogen activated protein kinase ( MAPK ) activation was required for LPS- and TNF-alpha induced, but not IL-10 induced, CD44-HA binding in normal monocytes
Chen et al., J Cell Physiol 2003 : LPS caused a biphasic activation of p42/44 MAPKs, an early increase peaking at 30 min and a second sustained phase, lasting up to 24 h ; LPS also caused an early and sustained increase p38 MAPK activity
Hou et al., Neuroreport 2003 : Sesamin or sesamolin significantly reduced LPS activated p38 MAPK of BV-2 cells
Peng et al., Cardiovasc Res 2003 (Acute Disease...) : LPS rapidly increased phosphorylation of p38 MAPK , followed by TNF-alpha mRNA expression and protein expression in the LV myocardium
Ma et al., Am J Physiol Lung Cell Mol Physiol 2004 : To elucidate the mechanisms of action, we show that oxidized PAPC, but not nonoxidized PAPC, inhibits the LPS- and CpG induced activation of p38 MAPK and the NF-kappaB cascade
Ikezoe et al., Mol Pharmacol 2003 (Shock, Septic) : Also, we explored the effect of PCSPES on LPS induced mitogen activated protein ( MAP ) kinase signaling ; PC-SPES did not affect LPS induced phosphorylation of MAP kinases, including c-Jun NH2-terminal kinase, p38, and extracellular signal regulated kinase 1/2
Ho et al., Br J Pharmacol 2004 (Inflammation) : Our data clearly indicated an inhibition ( IC ( 50 ) =1.7 microm ) of LPS mediated p38 MAPK activity, but not of extracellular signal regulated kinase ( ERK ) or c-Jun N-terminal kinase (JNK) activity
Cao et al., J Immunol 2004 (MAP Kinase Signaling System) : Previous reports indicated that LPS induced mitogen activated protein kinase activation is down-regulated by phosphatidylinositol 3-kinase through the activation of Akt
Fang et al., J Immunol 2004 (Inflammation) : Results indicated that LPS induced MAPK phosphorylation is enhanced in SHIP ( +/+ ) cells, whereas Akt phosphorylation is enhanced in SHIP ( -/- ) cells compared with SHIP ( +/+ ) cells
Migita et al., FEBS Lett 2004 : Stimulation of human hepatocytes with LPS results in rapid degradation of IkappaB-alpha and mitogen activated protein kinase activation
Kamezaki et al., Int Immunol 2004 (MAP Kinase Signaling System...) : The activation of MAPK and NF-kappaB by LPS , and the production of TNF-alpha and IL-12 after LPS injection, were not abrogated by the absence of Tyk2, Stat1 or Stat4
Baker et al., Endocrinology 2004 (MAP Kinase Signaling System) : In addition, we show that E ( 2 ) alters LPS stimulated MAPK pathway activation, supporting the idea that alterations in the MAPKs may be a potential mechanism by which ERbeta mediates decreased microglial activation
Alexander et al., J Cell Physiol 2004 (Burns...) : LPS stimulated inflammatory mediator production and MAPK expression ( P38 ERK 1/2 and JNK ) were determined ... Burn injury increased LPS induced P38 MAPK , suppressed JNK activation and ERK 1/2 activation was unaltered
Itoh et al., J Anesth 2004 : Halothane or isoflurane augmented the LPS- and TNF induced activation of p38 MAPK
Chen et al., J Leukoc Biol 2004 (Endotoxemia) : Consistently, an endogenous, immunosuppressive molecule, spermine, failed to inhibit LPS induced activation of p38 MAPK and yet, still significantly attenuated LPS mediated HMGB1 release
Denkers et al., Immunol Rev 2004 (Toxoplasmosis) : During early infection, nuclear translocation of NF-kappaB is blocked, and later, the cells display defects in lipopolysaccharide (LPS) induced MAPK phosphorylation after undergoing initial activation in response to Toxoplasma itself
Lonergan et al., J Neurochem 2004 (Brain Diseases) : The data indicate that treatment of hippocampal neurones with EPA abrogated the LPS induced increases in phosphorylation of the mitogen activated protein kinase , c-Jun N-terminal kinase (JNK), the transcription factor, c-Jun and the mitochondrial protein, Bcl-2
Leon-Ponte et al., Immunol Lett 2005 : Here, we show that the polycationic lipid LipoFectamine causes inhibition of the LPS induced MAPK activation and lack of pro-inflammatory cytokine production, despite proper localization of CD14 within lipid rafts and massive LPS internalization
Jeng et al., Immunol Lett 2005 : Sesamin and sesamolin also reduced LPS activated p38 mitogen activated protein kinase ( MAPK ) and nuclear factor (NF)-kappaB activations
Fiebich et al., Planta Med 2005 : C and D did not affect the LPS induced activation of p38 MAPK and IkappaBalpha, but they prevented the LPS induced activation of p42/44 MAPK
An et al., Blood 2005 (Inflammation) : SHIP1 also significantly inhibits LPS induced mitogen activated protein kinase ( MAPK ) activation in TLR4 reconstitited COS7 cells
Chino et al., Int Immunopharmacol 2005 (MAP Kinase Signaling System) : In PEMs treated with TJ-48, LPS induced phosphorylation of p65 NF-kappa B and p38 MAPK was augmented, while that of JNK and ERK was attenuated compared with those in vehicle PEMs
Kim et al., Immunopharmacol Immunotoxicol 2005 : Mercury activated p38 mitogen activated protein kinase ( MAPK ) and additively increased LPS induced p38 MAPK phosphorylation
Wu et al., Am J Physiol Heart Circ Physiol 2005 : Inhibitor studies in endothelial cells demonstrated a critical role for PKC in mediating thrombin, TNF-alpha, and LPS induction of ICAM-1, TF, and u-PA and for p38 MAPK in mediating thrombin, TNF-alpha, and LPS induction of TF
Lo et al., J Ethnopharmacol 2005 (Pulmonary Edema) : Western blotting analysis results indicated that all of them significantly inhibited LPS induced iNOS, TGF-beta, p38MAPK , and ICAM-1 expressions in the lung tissues
Husted et al., J Surg Res 2005 : The data show that delta2- but not delta1-opioid agonists suppress LPS induced p38 MAPK activation and expression of TNFalpha and MIP-2
Kim et al., J Immunol 2005 : Curcumin inhibited LPS induced MAPK activation and the translocation of NF-kappaB p65
Schnyder-Candrian et al., J Immunol 2005 (Leukocytosis...) : In conclusion, LPS provokes acute bronchoconstriction that is TNF dependent and p38 MAPK mediated, whereas the neutrophil recruitment is independent of TNF but depends on LPS/TLR4 induced signals mediated by p38 MAPK
Cheng et al., Shock 2005 : Pb + LPS coexposure significantly increased phosphorylation of p42/44 MAPK and TNF-alpha expression in peripheral blood cells ; however, exposure to Pb + LPS did not induce TNF-alpha, NO, or LPO production and p42/44 MAPK activation in the liver
Imahara et al., Surgery 2005 : In a randomly chosen subgroup, ( 8 men, 4 women ), peripheral blood mononuclear cells were isolated, and LPS mediated intracellular mitogen activated protein kinase ( MAPK ) phosphorylation was assayed via Western blot analysis
Hou et al., J Biomed Sci 2006 (Brain Ischemia) : BT significantly reduced LPS induced NF-kappaB and p38 MAPK activation
Murakami et al., J Nutr 2005 (Neoplasms) : Because SB203580 but not zerumbone suppressed LPS induced p38 MAPK activation , the molecular targets of zerumbone may be MAPK activated protein kinase-2 or located downstream
Maezawa et al., Journal of neuroinflammation 2006 : Our results suggest that LPS activation of innate immune response in TR APOE glia results in opposing outcomes from microglia and astrocytes as a result of TR APOE dependent activation of p38MAPK or NF-kappaB signaling in these two cell types
Kitamura et al., J Cell Biochem 2006 (MAP Kinase Signaling System) : LPS induced the proliferation of pulp cells through the activation of p38 MAPK
Liu et al., J Neurosci Res 2006 : NO had no effect on LPS stimulated ERK1/2 and p38 MAPK activation, suggesting that the inhibitory action of NO occurs downstream of MAPK cascades
Pérez de Diego et al., J Allergy Clin Immunol 2006 (Agammaglobulinemia...) : Monocyte LPS induced mitogen activated protein kinase activation , TNF-alpha and IL-6 production in monocytes, and oxidative burst in monocytes and granulocytes were analyzed by means of flow cytometry ... We show that in response to LPS , Btk-null monocytes from patients with XLA induce early mitogen activated protein kinase activation and intracellular TNF-alpha and IL-6 production with the same intensity as cells from age- and sex matched control subjects
Chen et al., Eur J Pharmacol 2006 : Dipyridamole also inhibited LPS stimulated p38 mitogen activated protein kinase ( p38 MAPK ) and IkappaB kinase-beta (IKK-beta) activities in RAW 264.7 cells
Yoon et al., Mol Pharmacol 2006 : The LPS induced activation of mitogen activated protein kinase , the nuclear translocation of its nuclear factor-kappaB p65 subunit, and the induction of the T-helper 1 response were all impaired in the presence of apigenin, whereas the cell mediated immune response remained normal
Motzkus et al., FASEB J 2006 (Sepsis) : Accordingly, DEFB123 abolished LPS mediated MAPK induction in these cells
Kim et al., Toxicology 2006 : SB203580 substantially suppressed LPS induced rises in p38 MAPK phosphorylation, neutrophil recruitment, total protein content in bronchoalveolar lavage fluid, and apoptosis of bronchoalveolar cells
Lucchi et al., J Reprod Immunol 2007 : LPS induces secretion of chemokines by human syncytiotrophoblast cells in a MAPK dependent manner
Chung et al., Endocrinology 2006 (Inflammation...) : LPS induced proinflammatory cytokine/chemokine expression and nuclear factor-kappaB and MAPK signaling decreased as differentiation increased ... Collectively, these data demonstrate that LPS induces nuclear factor-kappaB- and MAPK dependent proinflammatory cytokine/chemokine expression primarily in preadipocytes, which triggers the suppression of PPARgamma activity and insulin responsiveness in human adipocytes
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : We found that acacetin also inhibited LPS induced activation of PI3K/Akt and p44/42, but not p38 MAPK
Cuschieri et al., J Leukoc Biol 2006 : LPS stimulation of naïve cells resulted in TLR4 and heat shock protein ( HSP ) 70 lipid raft mobilization, MAPK activation, and TNF-alpha production
Patil et al., Oral Microbiol Immunol 2006 (MAP Kinase Signaling System) : The contribution of p38 MAPK LPS induced IL-6 expression was confirmed using MKK-3/6 dominant negative stable mPDL cell lines
Emre et al., Biochem J 2007 : Mitochondria contribute to LPS induced MAPK activation via uncoupling protein UCP2 in macrophages
Masek et al., J Cell Sci 2006 (Toxoplasmosis, Animal) : Here we report that host cell Ca ( 2+ ) is required for activation of MAPK by T. gondii, as well as LPS and CpG, and for parasite induced synthesis of IL-12
Thorley et al., J Immunol 2007 : Macrophage ( but not ATII cell ) responses to LPS required activation of ERK1/2 and p38 MAPK signaling cascades ; phosphorylated ERK1/2 was constitutively up-regulated in ATII cells
Kang et al., Pharmacol Res 2007 : Furthermore, EAAD suppressed LPS induced phosphorylation of p38 MAPK and extracellular-signal regulated kinases 1/2 ( ERK1/2 ), I-kappaBalpha degradation, and NF-kappaB activation in RAW 264.7 cells
Akilov et al., J Leukoc Biol 2007 (Disease Models, Animal...) : Inhibition of MP responses is a hallmark of Leishmania infection ; our data demonstrate further that host MR is not essential for blocking IFN-gamma/LPS induced IL-12 production and MAPK activation by Leishmania
Bodet et al., J Cell Physiol 2007 (Connective Tissue Diseases) : More specifically, they suggested that A. actinomycetemcomitans LPS may induce both Jun N-terminus protein-serine kinases ( JNK ) and mitogen activated protein-serine kinase p38 alpha ( p38alpha MAPK ) pathway activation, leading to increased activator protein-1 (AP-1) and nuclear factor kappa-B (NFkappaB) activities, which in turn can stimulate MMP-2, MMP-3, TIMP-1, and urokinase-type plasminogen activator ( uPA ) expression
Lin et al., Cell Signal 2007 : Consistently, LPS stimulated phosphorylation of p42/p44 MAPK and p38 was attenuated by pretreatment with U0126 or SB202190, and transfection with these siRNAs, respectively
Jeyaseelan et al., J Immunol 2007 (Escherichia coli Infections...) : E. coli LPS induced late MAPK activation, and TNF-alpha and IL-6 production were abolished in BMMs of TRIF ( -/- ) mice
Wang et al., Blood 2007 : Here we demonstrate that Rab7b can negatively regulate lipopolysaccharide (LPS) induced production of tumor necrosis factor (TNF)-alpha, IL-6, nitric oxide, and IFN-beta, and potentiate LPS induced activation of mitogen activated protein kinase , nuclear factor kappaB, and IFN regulatory factor 3 signaling pathways in macrophages by promoting the degradation of TLR4
Brooks et al., Inflamm Res 2007 (Endotoxemia...) : In vivo, LPS stimulates TxA2 production and p38 MAPK phosphorylation in equine platelets and leukocytes at a concentration within a similar range to those reported in clinical endotoxaemia
Eckert et al., Vet Immunol Immunopathol 2007 : LPS stimulation activated p38 MAPK and increased COX-2 expression in a dose dependent manner with maximal activation observed after 30min and 4h, respectively, at a concentration of 10 ng/ml LPS
Hung et al., Pediatr Allergy Immunol 2007 : The suppressive effect on MDC and IP-10 may, at least in part, involve the down-regulation of LPS induced p38 and ERK-MAPK expression
Gutiérrez-Venegas et al., Int Immunopharmacol 2007 : In this study, we investigated the role of the previously mentioned flavonoids on mitogen activated protein kinase ( MAPK ) activation induced by LPS obtained from P. gingivalis
Shen et al., J Mol Cell Cardiol 2007 : PLCgamma1 activation by LPS also increased ERK1/2 MAPK phosphorylation, and inhibition of ERK1/2 MAPK blocked the effect of PLCgamma1 on COX-2 expression ... The phosphorylation of ERK1/2 MAPK induced by LPS was also attenuated in U73122- or PLCgamma1 ( +/- ) compared to U73343 treated or wild-type littermate hearts, respectively
Handley et al., Int Immunol 2007 (MAP Kinase Signaling System) : Inhibition of MLK activity using a pharmacological inhibitor, CEP11004, blocks p38 and Jun N-terminal kinase (JNK) MAPK activation in response to LPS and poly ( I:C ), but not zymosan
Qin et al., J Immunol 2007 (MAP Kinase Signaling System) : These results indicate that LPS induced MAPK activation, the production of endogenous IL-10, and STAT-3 activation play critical roles in SOCS-3 expression, which provides for feedback attenuation of cytokine induced immune and inflammatory responses in macrophages and microglia
Zhou et al., J Immunol 2007 (Bacteroidaceae Infections) : Taken together, these data demonstrate that P. gingivalis and its components induce NFkappaB containing genes through either TLR2- or TLR7-MyD88-p38 MAPK pathway, while P. gingivalis LPS uniquely induces ISRE containing genes, which requires IFNalphabetaR signaling involving IRF7, KLF4, and pY701 STAT1
Kim et al., Arch Pharm Res 2007 (Periodontitis) : In addition, NAC prevented LPS induced activation of p38 MAPK and JNK but not phosphorylation and subsequent degradation of IkB
Jung et al., Exp Mol Med 2007 (Inflammation) : The molecular mechanisms that underlie celastrol mediated attenuation were the inhibition of LPS induced phosphorylation of MAPK/ERK1/2 and the DNA binding activity of NF-kappaB in BV-2 cells
Wu et al., Toxicol Appl Pharmacol 2008 : TLR4 was expressed on THP-1 cells and pretreatment of cells with a Toll-like receptor 4 (TLR4) neutralizing antibody ( HTA125 ) significantly blunted LPS induced MAPK and NFkappaB activation and ensuing CD40 expression
Xing et al., Journal of neuroinflammation 2008 (Encephalitis) : Further, and of interest, pioglitazone inhibited LPS induced phosphorylation of p38 MAPK
Kim et al., J Immunol 2008 (MAP Kinase Signaling System...) : In this study, the effect of Lactobacillus plantarum lipoteichoic acid ( pLTA ) on LPS induced MAPK activation, NF-kappaB activation, and the expression of TNF-alpha and IL-1R associated kinase M (IRAK-M) was examined
Yoo et al., Neurochem Int 2008 (Encephalitis...) : LPS+IFN-gamma induced p38 MAPK activation and ONOO ( - ) generation were attenuated by SB203580 or SKF-86002, specific inhibitors of p38 MAPK
Dohgu et al., Exp Neurol 2008 : LPS also increased the phosphorylation of p44/42 MAPK and p38 MAPK but not that of JNK
Hickey et al., J Leukoc Biol 2008 : CyaA enhanced LPS induced phosphorylation of p38 MAPK and ERK in DC, and inhibitors of p38 MAPK , MEK, or NF-kappaB suppressed IL-10 production in response to LPS and CyaA
Ahn et al., Arch Dermatol Res 2008 (MAP Kinase Signaling System) : LPS induces melanogenesis through p38 MAPK activation in human melanocytes
Lee et al., J Pharm Pharmacol 2008 : To further elucidate the mechanism of this inhibitory effect of eutigoside C, we studied LPS induced nuclear factor (NF)-kappaB activation and mitogen activated protein ( MAP ) kinase phosphorylation
Orellana et al., Pediatr Res 2008 (Disease Models, Animal...) : In liver, activation of the insulin receptor, IRS-1, and PI 3-kinase were not affected by LPS , but p42 MAPK phosphorylation was increased
Pan et al., J Agric Food Chem 2008 : We found that pterostilbene also inhibited LPS induced activation of PI3K/Akt, extracellular signal regulated kinase 1/2 and p38 MAPK
Shi et al., Blood 2008 (Gram-Negative Bacterial Infections...) : Furthermore, rTMD1 modulated LPS induced mitogen activated protein kinase and nuclear factor-kappaB signaling pathway activations and inducible nitric oxide synthase expression in macrophages
Park et al., Cytokine 2008 : Pretreatment of cells with nicotine blocked LPS induced p42/44 MAPK and S6K1 as well as iNOS promoter activity
Kim et al., Mol Cells 2008 : In addition, rosmarinic acid reduced cell migration by inducing the expression of a specific chemokine receptor on LPS induced mature BMDCs. Rosmarinic acid also significantly reduced the expressions of MCP-1 and MIP-lalpha induced by LPS in BMDCs and inhibited LPS induced activation of MAPK and the nuclear translocation of NF-kappaB
Kang et al., Eur J Pharmacol 2008 : The LPS induced phosphorylation of p38 MAPK and extracellular signal regulated kinase 1/2 ( ERK1/2 ) was inhibited by PA, but not the phosphorylation of JNK 1/2 and AKT ( Ser473 )
Anand et al., Mol Immunol 2009 (MAP Kinase Signaling System...) : Inhibition of Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly attenuated LPS induced Pyk2 tyrosine phosphorylation, p38 MAP kinase ( MAPK ) activation, NF-kappaB activation, and MCP-1 expression
Fu et al., Eur Respir J 2009 (Inflammation) : In vivo, concurrent amifostine administration inhibited LPS induced oxidative stress and p38 mitogen activated protein kinase activation, which was associated with reduced vascular leak and neutrophil recruitment to the lungs
Miksa et al., Int J Mol Med 2008 (Inflammation) : Differential MAPK activation may play a role in the enhanced LPS responsiveness of RPM and the lack of MFG-E8 impedes post-phagocytic suppression of LPS-response through the inhibition of those signaling pathways
El-Remessy et al., Molecular vision 2008 (Uveitis) : At a later phase, LPS induced NO, ROS, and p38 MAPK activation that peaked at 2-6 h and was accompanied by morphological change of microglia
Neuder et al., Vet Immunol Immunopathol 2009 : Role of p38 MAPK in LPS induced pro-inflammatory cytokine and chemokine gene expression in equine leukocytes
Brooks et al., Vet Immunol Immunopathol 2009 : These results reveal a key role for p38 MAPK in the response of the endothelium to LPS and suggest that inhibition of this kinase may reduce inflammatory events in the endotoxemic horse
Walton et al., Am J Physiol Gastrointest Liver Physiol 2009 : LPS induced rapid phosphorylation of NF-kappaB p65, Akt, and p38 MAPK and degradation of Ikappa-Balpha
Tsukimoto et al., Radiat Res 2009 : Since activated p38 MAPK mediates TNF-alpha production, we examined the effect of radiation on LPS induced activation of p38 MAPK and TNF-alpha production ... The activation of p38 MAPK and production of TNF-alpha induced by LPS treatment were both suppressed in preirradiated cells
Wang et al., Arch Biochem Biophys 2009 : The LPS induced phosphorylation of p38 MAPK and JNK were inhibited by EGFR inhibitor
Mandrekar et al., J Hepatol 2009 (Hepatitis, Alcoholic...) : In addition, LPS induced MAPK such as ERK and p38 also contribute to liver injury
Bumrungpert et al., J Nutr 2009 (Inflammation...) : Moreover, alpha- and gamma-MG attenuated LPS activation of the mitogen activated protein kinases ( MAPK ) c-jun NH ( 2 ) -terminal kinase, extracellular signal related kinase, and p38
Surriga et al., Immunol Lett 2009 (Hepatitis) : Furthermore, maternal immune activation attenuated LPS induced phosphorylation of p42/44 MAPK compared with the control pups without significantly affecting the phosphorylation of p38 MAPK
Abe et al., Clin Exp Immunol 2009 : In comparison with LPS stimulation, LPS-ICs stimulation enhanced p38 MAPK phosphorylation significantly, which was associated with an increase in IL-12 p40 monomer/homodimer secretion
Li et al., Int Arch Allergy Immunol 2009 : Inhibition of ERK, JNK or p38 MAPK had little discernible effect on LPS-inducible CRAMP gene expression
Jung et al., Int J Immunopathol Pharmacol 2009 : Apicidin also inhibited LPS induced MAPK activation and NF-kB nuclear translocation in DCs
Lacour et al., J Immunotoxicol 2009 : Moreover, we found that p38MAPK , JNK, and ERK were activated by APAP or LPS alone or in association
Feng et al., Atherosclerosis 2010 : In addition, LPS induced the phosphorylation of p38MAPK and translocation of NF-kappaB p65, contributing to the up-regulated expression of Fcamr in macrophages as treatment with specific inhibitor for p38MAPK ( SB203580 ) or NF-kappaB ( PDTC ) attenuated the up-regulation of Fcalpha/mu receptor expression induced by LPS in macrophages
Zhang et al., Br J Pharmacol 2009 : These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via CRF ( 2 ) receptors and the activation of p38MAPK and NF-kappaB
Oh et al., Neurosci Lett 2009 : We also showed that OA inhibited LPS induced phosphorylation of Akt and p38 MAPK , but not that of ERK
Matera et al., Clinical and vaccine immunology : CVI 2009 : V. parvula LPS stimulated cytokine induction, as well as p38 MAPK activation, are TLR4 dependent features
Chon et al., Comp Immunol Microbiol Infect Dis 2010 : A specific protein fraction ( 8.7 kDa ) was found to be a strong IL-10 inducer in LPS stimulated RAW 264.7 cells and suppressed LPS induced NF-?B induction and inhibited LPS induced phosphorylation of I-?B and p38 MAPK
Boucher et al., Viral Immunol 2010 (HIV Infections...) : Disparate regulation of LPS induced MAPK signaling and IL-12p40 expression between different myeloid cell types with and without HIV infection ... Studies from our laboratory and those of others have implicated lipopolysaccharide (LPS) induced MAPK signaling as an important pathway in the regulation of cytokine expression
Svensson et al., Brain Res 2010 (Encephalitis...) : The level of phosphorylated JNK MAPK ( p46 ) was strongly increased by LPS alone and was further increased when combined with NAC
Brooks et al., Inflamm Res 2010 (Anoxia...) : The effect of LPS , but not 5 % O ( 2 ), on neutrophil adherence required activation of p38 MAPK , whereas EDVEC permeability in response to both stimuli was dependent on p38 MAPK and HIF-1alpha
Oh et al., Neurosci Lett 2010 (Inflammation) : We also showed that oleamide inhibited LPS induced phosphorylation of Akt, p38 MAPK , and ERK, activation of PI 3-kinase, and accumulation of reactive oxygen species ( ROS )
Tang et al., J Innate Immun 2010 (Shock, Septic) : We recently identified a LITAF-STAT6 ( B ) complex regulated by p38 MAPK in response to LPS stimulation
Liu et al., Biochem Biophys Res Commun 2010 (Pulmonary Disease, Chronic Obstructive) : Moreover, FGL2 knockdown in THP-1 cells significantly downregulated LPS induced phosphorylation of p38-MAPK while upregulating phosphorylation of c-Jun N-terminal kinase (JNK)
Chen et al., J Cell Biochem 2010 (Inflammation) : Silencing of integrin beta4 ( siITGB4 ) in human lung EC resulted in significant increases in both basal and LPS induced phosphorylation of ERK 1/2, JNK, and p38 MAPK , consistent with robust integrin beta4 regulation of MAPK activation
Gomez et al., J Biol Chem 2010 : In vitro and in vivo inhibition of PTP activity by iron-citrate results in protein hyperphosphorylation and enhanced MAPK signaling in response to LPS stimulation
Lee et al., J Med Food 2010 (MAP Kinase Signaling System) : HAK suppressed LPS induced c-Jun NH ( 2 ) -terminal kinase, p38, and p44/p42 MAPK activation
Lim et al., Eur J Pharmacol 2010 (MAP Kinase Signaling System) : In addition, pretreatment with isodojaponin D significantly attenuated LPS induced mitogen activated protein kinase ( MAPK ) activation
Jiang et al., J Mol Endocrinol 2010 : Furthermore, p38 MAPK is rapidly activated in response to LPS , while E ( 2 ) markedly inhibits p38 MAPK activation
Into et al., Cell Immunol 2010 (Bacterial Infections...) : LL-37 potently suppressed LPS induced gene expression of IL6, IL8 and CXCL10 and intracellular signaling events, degradation of IRAK-1 and IkappaBalpha and phosphorylation of p38 MAPK and IRF3, indicating that the LPS neutralizing activity is also exerted in HGFs. LL-37 also suppressed the expression of IL6, IL8 and CXCL10 induced by the TLR3 ligand poly ( I:C )
Park et al., Int Immunopharmacol 2010 (Shock, Septic) : To further elucidate the mechanism responsible for the inhibition of production of pro-inflammatory mediators by cilostazol, we examined the effect of cilostazol on LPS stimulated nuclear factor-kappaB (NF-kappaB) activation and phosphorylation of mitogen activated protein kinases ( MAPK )
Mizumura et al., Int Immunopharmacol 2010 (MAP Kinase Signaling System) : The results showed the following : 1 ) LPS induces hTF mRNA expression in normal human lung microvascular endothelial cells ( HMVEC-L ) ; 2 ) LPS induces ASK1 phosphorylation in HMVEC-L ; 3 ) LPS induced TF mRNA expression is depressed in the dominant negative form of ASK1 stably transfected porcine artery endothelial ( PAE ) cells ; 4 ) LPS stimulation induces p38 MAPK and JNK phosphorylations in HMVEC-L ; 5 ) LPS induced p38 MAPK and JNK phosphorylations are depressed in the dominant negative form of ASK1 stably transfected PAE cells ; and 6 ) SB 203580 as a specific inhibitor of p38 MAPK, but not SP 600125 as a specific inhibitor of JNK cascade, attenuates LPS induced hTF mRNA expression
Li et al., Planta Med 2011 (Memory Disorders) : LPS induced activation of p38 MAPK and NF- ?B pathway was also suppressed
Koch et al., Neonatology 2011 : As both nuclear factor-kappa B ( NF-?B ) and p38 mitogen activated protein kinase ( MAPK ) appear to be critical mediators in inflammatory response, we studied the effects of lipopolysaccharide (LPS) on expression and function of NF-?B and p38 MAPK in whole neonatal cord and adult blood ... Stimulation with LPS resulted in significantly decreased activation of p38 MAPK in neonatal blood, whereas NF-?B showed no difference ... We conclude that p38 MAPK phosphorylation is crucially involved in LPS activation and could explain the differences in early cytokine response between neonatal and adult blood
Jung et al., J Neurochem 2010 : Subsequent mechanistic studies revealed that Rh1 inhibited LPS induced MAPK phosphorylation and nuclear factor-?B ( NF-?B ) -mediated transcription without affecting NF-?B DNA binding
Kim et al., J Ethnopharmacol 2011 (Endotoxemia) : As a result, MTO inhibited pro-inflammatory cytokines such as TNF-a and IL-6, which is hypothesized as being due to the suppression of LPS induced p38 MAPK and NF-?B activation
Holen et al., Fish Shellfish Immunol 2011 : Indicating a p38 MAPK feedback loop, LPS significantly inhibited the expression of p38MAPK itself in both diets, while SB202190 increased p38MAPK expression especially in the VO diet group
Sarkar et al., Mol Cell Biol 2011 : Indeed, knockdown of AUF1 impairs LPS mediated p38 mitogen activated protein kinase ( MAPK ) and NF-?B signaling, and the expression of an RNA interference-refractory p40 ( AUF1 ) cDNA restores both signaling pathways
Bulua et al., J Exp Med 2011 (Cryopyrin-Associated Periodic Syndromes...) : A variety of antioxidants dampen LPS induced MAPK phosphorylation and inflammatory cytokine production
Ma et al., Hum Mutat 2011 (Ectodermal Dysplasia...) : Here we show that dendritic cells from patients with EDI caused by a C-terminal E391X deletion of the zinc finger of NEMO exhibit impaired MAPK activation in response to lipopolysaccharide (LPS) stimulation
Qian et al., J Immunol 2011 (Parkinson Disease) : Salmeterol significantly inhibited LPS induced production of microglial proinflammatory neurotoxic mediators, such as TNF-a, superoxide, and NO, as well as the inhibition of TAK1 mediated phosphorylation of MAPK and p65 NF-?B
Kang et al., J Ethnopharmacol 2011 (Inflammation) : The extract also inhibited LPS induced I?Ba degradation and MAPK activation as well as LPS/IFN-? induced STAT1 activation , effects observed at a higher concentration than that required to suppress iNOS
Huang et al., Immunopharmacol Immunotoxicol 2011 (Bronchitis, Chronic...) : Previous studies have investigated effect of LPS on MAPK activation in macrophage of normal rats
Kanoh et al., Chest 2011 (Bronchitis...) : LPS led to phosphorylation of extracellular signal regulated kinase 1/2, but not p38 MAPK or c-Jun NH ( 2 ) -terminal kinase
Park et al., Br J Pharmacol 2011 : Moreover, kaempferol inhibited LPS induced NF-?B activation and p38 MAPK , JNK and AKT phosphorylation
Watanabe et al., Biochem Biophys Res Commun 2011 : Notably, the extract enhanced LPS induced phosphorylation of p38 mitogen activated protein kinase ( MAPK ), while it suppressed LPS induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK
Huang et al., J Food Sci 2010 (Hypersensitivity...) : We also found that kaempferol was able to suppress LPS induced mitogen activated protein kinase ( MAPK ) pathways, as well as the phosphorylation of upstream c-raf and MEK1/2
Wu et al., J Surg Res 2012 : LPS induced p38 MAPK activation and NF-?B signal pathways first, followed by CBP activation
Zhan et al., Mol Biol Rep 2012 : LPS treatment significantly induced p38 MAPK activation, iNOS expression, and NO production, which could be attenuated by 2 µg/ml PHC pretreatment
Kasahara et al., FEBS Lett 2011 (MAP Kinase Signaling System) : These results suggest that mitochondrial density and/or the respiratory state contribute to intracellular oxidative stress, which is responsible for the stimulation of LPS induced MAPK signaling to enhance cytokine release from macrophages
Du et al., J Immunol 2011 (Arthritis, Experimental) : Rg1 also displayed profound inhibitory effects on LPS induced MAPK activation
Zhang et al., Inflamm Res 2011 (Inflammation) : Meanwhile, the activation of p38 MAPK and c-Jun N-terminal kinases (JNK) induced by LPS were decreased by MHNA
Lin et al., J Pharmacol Exp Ther 2011 (Acute Lung Injury...) : LPS activated phosphorylation of p38 MAPK also was attenuated by treatment with Sph-24 and sphingosine kinase inhibitor II
Fu et al., Atherosclerosis 2011 (MAP Kinase Signaling System) : The mechanistic investigations of XJP-1 suppression LPS induced inflammation in HUVECs revealed that XJP-1 blocked NF-?B nuclear entry in an I?B dependent manner, as well as inhibited MAPK activation induced by LPS
Hankins et al., J Biol Chem 2011 : Specifically, C-1-P prevents the degradation of I?B, the phosphorylation of the p65 subunit of NF-?B, and LPS stimulated MAPK activation
Fiebich et al., Phytother Res 2012 (MAP Kinase Signaling System) : The extract had no effect on the LPS induced binding of nuclear factor-?B in RAW 264.7 cells, on LPS induced degradation of I?Ba or on LPS induced activation of mitogen activated protein kinases ( MAPK ), p38MAPK and JNK in human monocytes
Kim et al., FEMS Microbiol Lett 2012 (Inflammation) : The effect of Lactobacillus plantarum genomic DNA on lipopolysaccharide (LPS) induced mitogen activated protein kinase ( MAPK ) activation , nuclear factor-kappa B activation, and the expressions of tumor necrosis factor-alpha, interleukin-1 receptor associated kinase M, and the pattern recognition receptor were examined
Xing et al., Molecular neurodegeneration 2011 (Inflammation...) : The findings also provide evidence that a major mechanism by which LPS activation of microglia p38a MAPK signaling leads to neuron damage is through up-regulation of the proinflammatory cytokine TNFa
Avila et al., Innate Immun 2012 : LPS induced MAPK and inhibitor of I?B kinase ( IKK ) phosphorylation were importantly reduced in the absence of Lyn
Zhu et al., J Immunol 2012 : LPS mediated MAPK activation was enhanced in LAB ( -/- ) bone marrow derived dendritic cells
Zhai et al., Mol Biol Rep 2012 (Glomerulonephritis, Membranoproliferative...) : We demonstrated that PDTC inhibited LPS induced monocyte migration and attenuated LPS induced p38 MAPK activation
de Jong et al., PloS one 2012 (Inflammation) : LPS induced p38 mitogen activated protein kinase ( MAPK ) and nuclear factor ( NF ) -?B activation by patient plasma was assessed by Western blotting
Joo et al., Gut and liver 2012 : Epigallocatechin-3-gallate Inhibits LPS Induced NF-?B and MAPK Signaling Pathways in Bone Marrow Derived Macrophages ... The effect of EGCG on LPS induced pro-inflammatory gene expression and nuclear factor-?B ( NF-?B ) and mitogen activated protein kinase ( MAPK ) signaling was examined using reverse transcription-polymerase chain reaction, Western blotting, immunofluorescence, and the electrophoretic mobility shift assay
Liu et al., PloS one 2012 (Shock, Septic) : In the present study, we show that a novel chromone derivative, DCO-6, significantly reduced lipopolysaccharide (LPS) induced production of nitric oxide, IL-1ß and IL-6, decreased the levels of iNOS, IL-1ß and IL-6 mRNA expression in both RAW264.7 cells and mouse primary peritoneal macrophages, and inhibited LPS induced activation of p38 MAPK but not of JNK, ERK
Su et al., Int Immunopharmacol 2012 : Upon LPS stimulation, fluoxetine caused a delay but increased in the phosphorylated levels of GSK-3ß ( ser9 ), whereas it did not affect LPS induced activation of mitogen activated protein kinase ( MAPK ) and generation of reactive oxygen species ( ROS )
Birukova et al., Eur Respir J 2013 (Lung Injury) : Iloprost induced elevation of intracellular cAMP triggers Rac signalling, which attenuates LPS induced NF-?B and p38 MAPK inflammatory pathways and the Rho dependent mechanism of endothelial permeability
Zawadzka et al., J Mol Med (Berl) 2012 (Inflammation...) : FK506 strongly reduced LPS induced activation of MAPK , and its downstream signaling crucial for inflammatory responses
Yang et al., J Mol Med (Berl) 2013 (Endotoxemia...) : LPS caused p38 MAPK- , JNK-, and PI3K/AKT mediated Mcl-1 stabilization and prevented apoptosis, and LPS induced GSK-3ß inactivation mainly through p38 MAPK and PI3K/AKT
Liu et al., Chinese medicine 2012 : This study demonstrates that a-MG attenuates LPS mediated activation of MAPK , STAT1, c-Fos, c-Jun and EIK-1, inhibiting TNF-a and IL-4 production in U937 cells
Soliman et al., J Neurochem 2012 : LPS increased p38 MAPK and JNK phosphorylation at 4 and 2-4 h, respectively, whereas treatment reduced p38 MAPK and JNK phosphorylation only at 2 h
Zbinden-Foncea et al., Cell Biol Int 2012 : Downregulation of either tlr2 or tlr4 gene expression by small interfering RNAs prevented the activation of both p38 MAPK and S6K1 by FSL-1, LPS or PA
Xu et al., J Int Med Res 2012 (MAP Kinase Signaling System...) : Naloxone also dose-dependently inhibited LPS induced increases in phosphorylated p38 MAPK
Park et al., J Periodontal Res 2013 : Resveratrol and Ad-SIRT1 decreased LPS and nicotine induced cytotoxicity, ROS and PGE2 production, and expression of cyclooxygenase-2 in HGFs. Resveratrol and Ad-SIRT1 inhibited nicotine and LPS mediated protein kinase C ( PKC ), phosphatidylinositol 3-kinase (PI3K), p38, ERK, JNK, MAPK and nuclear factor-kappa B ( NF-?B ) activation
Barry et al., Cell Host Microbe 2012 : Impaired stimulation of p38a-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes ... We find that while avirulent C. burnetii LPS ( avLPS ) stimulates host p38a-MAPK signaling required for proper trafficking of bacteria containing compartments to lysosomes for destruction, pathogenic C. burnetii LPS ( vLPS ) does not
Byun et al., Int Immunopharmacol 2013 (Inflammation...) : The procyanidin trimer C1 inhibits LPS induced MAPK and NF-?B signaling through TLR4 in macrophages
Lee et al., J Ethnopharmacol 2013 (Disease Models, Animal...) : Treatment of primary macrophages with TCC in vitro significantly inhibited all of the inflammatory parameters measured, including LPS induced NO and PGE ( 2 ) production, iNOS and COX-2 expression, I?Ba degradation, IKK phosphorylation, and MAPK and STAT1 activation
Wei et al., J Anesth 2013 : The present study investigated the anti-inflammatory effect and mechanism of propofol on MCP-1 production and mitogen activated protein kinase ( MAPK ) phosphorylation induced by lipopolysaccharide (LPS) in alveolar epithelial cells ( AECs )
Piao et al., J Immunol 2013 (Inflammation) : Peptides derived from TRAM TIR BB loop ( TM4 ) and C helix ( TM6 ) inhibited the LPS induced activation of MyD88 dependent and TRIF dependent cytokines, as well as MAPK activation
Frei et al., J Allergy Clin Immunol 2013 (Inflammation) : Histamine suppressed MDDC chemokine and proinflammatory cytokine secretion, nuclear factor ?B and activator protein 1 activation, mitogen activated protein kinase phosphorylation, and TH1 polarization of naive lymphocytes, whereas IL-10 secretion was enhanced in response to LPS and Pam3Cys
Edan et al., PloS one 2013 : In the present study we found that administration of chemically modified tetracycline-3 ( COL-3 ), inhibits lipopolysaccharide (LPS) induced microglial and p38 MAPK activation, as well as the increase in TNF-a, but not IL-1ß expression, in the brains of BALB/c mice
Fu et al., PloS one 2013 (Inflammation) : Moreover, acetylcorynoline significantly inhibits LPS induced activation of I?B kinase and mitogen activated protein kinase
Fan et al., Neuroscience 2013 (Disease Models, Animal...) : Celecoxib administration significantly attenuated systemic LPS induced increments in the number of activated microglia and astrocytes, concentrations of IL-1ß and TNFa, and protein levels of phosphorylated-p38 MAPK in the neonatal rat brain
Xu et al., CNS Neurosci Ther 2013 : In addition, according to the study of related signaling pathways, RvD1 attenuated LPS induced microglia NF-?B activation, MAPK phosphorylation, and activator protein-1 transcriptional activity
Aerbajinai et al., J Immunol 2013 : We show that GMFG negatively regulates LPS induced activation of NF-?B-, MAPK- , and IRF3 signaling pathways and subsequent production of proinflammatory cytokines and type I IFN in human macrophages
Xiong et al., J Leukoc Biol 2013 (Immunologic Deficiency Syndromes...) : Whereas IRAK4 kinase deficiency decreased LPS signaling, it did not prevent endotoxin tolerance, as endotoxin pretreatment of WT and IRAK4 ( KDKI ) macrophages inhibited LPS induced MAPK phosphorylation, degradation of I?B-a and recruitment of p65 to the TNF-a promoter, expression of proinflammatory cytokines, and increased levels of A20 and IRAK-M
Glucksam-Galnoy et al., J Immunol 2013 : Finally, C12 substantially potentiated LPS stimulated NF-?B DNA binding levels and prolonged p38 MAPK phosphorylation in RAW264.7 macrophages, suggesting that increased transcriptional activity of NF-?B and/or p38 activated transcription factors serves to upregulate IL-10 production in macrophages exposed to both LPS and C12
Liu et al., J Immunol 2013 (MAP Kinase Signaling System) : We also show that LPS , through p38 MAPK signaling, induces phosphorylation of GRK2 at serine 670, which, in turn, suppresses GRK2 translocation to the membrane, thereby preventing GRK2 initiated internalization and desensitization of CCR2 in response to MCP-1
Sominsky et al., Frontiers in neuroscience 2013 : Several canonical pathways involved in immune recognition were affected by LPS treatment, such as nuclear factor-?B ( NF-?B ) activation and LPS stimulated mitogen activated protein kinase ( MAPK ) signaling
Chen et al., Clin Dev Immunol 2013 : Moreover, the inhibition of LPS induced MAPK activation and NF- ? B translocation may contribute to the suppressive effect of DXM on BMDCs. Remarkably, DXM decreased the LPS induced surface expression of CD80, CD83, and HLA-DR and the secretion of IL-6 and IL-12 in human monocyte derived dendritic cells ( MDDCs )
Wan et al., J Endocrinol 2013 : DHT enhanced LPS induced p38MAPK , ERK1/2, and nuclear factor ?B pathway activation, which may contribute to the elevated expression of UCN1
Iliev et al., Fish Shellfish Immunol 2013 : CpG- and LPS activated MAPK signaling in in vitro cultured salmon ( Salmo salar ) mononuclear phagocytes
Oh et al., Molecules (Basel, Switzerland) 2013 (Inflammation...) : The extract also had no effect on LPS stimulated p38 MAPK , JNK, and c-Jun phosphorylation, whereas ERK1/2 phosphorylation was strongly inhibited by BOWE
Büscher et al., Mol Cell Biol 1995 : Similarly, down-regulation or inhibition of protein kinase C blocked MEK and MAPK induction by LPS but not that by CSF-1
Ding et al., J Immunol 1993 : c ) Macrophages from C3H/HeJ mice, which carry a defective Lps gene, fail to activate MAPK in response to taxol or LPS , although they activate MAPK in response to insulin or IFN-gamma
Sanghera et al., J Immunol 1996 : Bacterial LPS stimulation of murine macrophages leads to increased tyrosine phosphorylation and activation of the 42- and 44-kDa mitogen activated protein kinases ( MAPK ) and the activation of stress activated protein kinases ( SAPK ) /c-Jun N-terminal kinase (JNK) and p38, related to the high osmolarity glycerol protein kinase in Saccharomyces cerevisiae ( HOG1 )
Ding et al., J Exp Med 1996 : Stimulation of macrophages by LPS quickly induces the activation of mitogen activated protein kinases ( MAPK )
Guthridge et al., Mol Cell Biol 1997 : This observation was supported by results from transfection studies which demonstrated that expression of a dominant-inhibitory Raf-1 mutant in RAW 264.7 cells does not inhibit LPS induced MAPK activity or sIL-1Ra promoter activity, indicating that LPS induced sIL-1Ra promoter activation occurs independent of the Raf-1/MAPK signaling pathway
Pyo et al., Neuroreport 1998 : These results suggest that MAPK , at least p38 and ERK, mediate LPS- , and Abeta induced microglial activation
Lo et al., J Surg Res 1998 : To further study the cellular mechanism of iloprost on M-theta activation, RAW 264.7 cells were stimulated by LPS ( 10 micrograms/ml ) in the presence of either iloprost or specific mitogen activated protein kinase ( MAPK ) inhibitors, either PD98059 or SB202190
Niiro et al., Biochem Biophys Res Commun 1998 : LPS induced the expression of COX-2 protein and COX-2 mRNA as well as the phosphorylation and activation of extracellular signal regulated protein kinase ( ERK ) 2 and p38 MAPK in monocytes
Solomon et al., J Clin Invest 1998 (Shock, Septic) : Furthermore, we demonstrate that heterotrimeric G proteins specifically regulate CD14 mediated, LPS induced mitogen activated protein kinase ( MAPK ) activation and cytokine production in normal human monocytes and cultured cells