Gene interactions and pathways from curated databases and text-mining

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GRAP2 — MEFV

Text-mined interactions from Literome

Burton et al., Brain Res Mol Brain Res 2002 (Alzheimer Disease...) : A model of anti-apoptotic APP signaling is proposed where APP mediates p38 MAPK dependent phosphorylation and activation of MEF2
Lee et al., Mol Cell Biol 2003 (MAP Kinase Signaling System) : We found TNF-alpha induced p38 MAP kinase activation and interleukin-6 (IL-6) production impaired in rip1 ( -/- ) murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF
McGee et al., Clin Exp Pharmacol Physiol 2006 : 3. These studies find possible roles for histone deacetylase 5 (HDAC5), adenosine monophosphate activated protein kinase ( AMPK ), peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC-1alpha ) and p38 mitogen activated protein kinase ( MAPK ) in regulating MEF2 through a series of complex interactions potentially involving MEF2 repression, coactivation and phosphorylation
Yin et al., Frontiers in physiology 2012 : Following the first demonstration that mitogen activated protein kinase p38 ( p38 MAPK ) directly phosphorylates and activates MEF2 to promote neuronal survival, several other kinase regulators of MEF2s have been identified