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GRAP2 — MEFV
Text-mined interactions from Literome
Burton et al., Brain Res Mol Brain Res 2002
(Alzheimer Disease...) :
A model of anti-apoptotic APP signaling is proposed where APP mediates
p38 MAPK dependent phosphorylation and
activation of
MEF2
Lee et al., Mol Cell Biol 2003
(MAP Kinase Signaling System) :
We found TNF-alpha induced
p38 MAP kinase
activation and interleukin-6 (IL-6) production impaired in rip1 ( -/- )
murine embryonic fibroblasts (MEF) but unaffected in traf2 ( -/- ) MEF
McGee et al., Clin Exp Pharmacol Physiol 2006
:
3. These studies find possible
roles for histone deacetylase 5 (HDAC5), adenosine monophosphate activated protein kinase ( AMPK ), peroxisome proliferator activated receptor gamma coactivator 1alpha ( PGC-1alpha ) and
p38 mitogen activated protein kinase ( MAPK ) in regulating
MEF2 through a series of complex interactions potentially involving MEF2 repression, coactivation and phosphorylation
Yin et al., Frontiers in physiology 2012
:
Following the first demonstration that mitogen activated protein kinase
p38 ( p38 MAPK ) directly phosphorylates and
activates MEF2 to promote neuronal survival, several other kinase regulators of MEF2s have been identified