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MID1 — PPP2R1A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Berti et al., BMC cell biology 2004
(Smith-Lemli-Opitz Syndrome) :
Mid1 acts as an E3 ubiquitin ligase,
regulating PP2A degradation on microtubules
Collison et al., Nat Med 2013
(Asthma...) :
siRNA mediated knockdown of
MID1 or pharmacological
activation of
PP2A using a nonphosphorylatable FTY720 analog in mice exposed to HDM reduces airway hyperreactivity and inflammation, including the expression of interleukin-25 (IL-25), IL-33 and CCL20, IL-5 and IL-13 release, nuclear factor ( NF ) ?B activity, p38 mitogen activated protein kinase ( MAPK ) phosphorylation, accumulation of eosinophils, T lymphocytes and myeloid dendritic cells, and the number of mucus producing cells
Du et al., J Biol Chem 2013
:
The MID1 E3 Ligase Catalyzes the Polyubiquitination of Alpha4 ( a4 ), a Regulatory Subunit of Protein Phosphatase 2A (PP2A) : NOVEL INSIGHTS INTO
MID1-MEDIATED REGULATION of
PP2A ... a4 forms a complex with PP2A and MID1, a microtubule associated ubiquitin E3 ligase that facilitates
MID1 dependent regulation of
PP2A and the dephosphorylation of MID1 by PP2A