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EPHB2 — MYC

Text-mined interactions from Literome

Cheng et al., J Biol Chem 1999 : Using the mitogen activated protein kinase kinase ( MEK1/2 ) inhibitor PD98059 and dominant negative forms of Ras ( N17 ) and ERK1 ( K71R ), we found that activation of Ras and extracellular signal regulated kinase ( ERK ) is necessary for colony stimulating factor-1 (CSF-1) mediated c-Myc expression and DNA synthetic ( S ) phase entry
Al-Assar et al., Molecular cancer 2005 (Cell Transformation, Neoplastic...) : Therefore, our main aim was to examine the levels of MAPK in Myc transformed cells in light of the roles of ERK in cell cycle and control of Myc protein levels
Sharma-Walia et al., J Virol 2005 (Herpesviridae Infections...) : Several MAPK regulated host transcription factors such as c-Jun, STAT1alpha, MEF2, c-Myc, ATF-2 and c-Fos were induced early during infection, and ERK inhibition significantly blocked the c-Fos, c-Jun, c-Myc , and STAT1alpha activation in the infected cells
Liu et al., Dig Liver Dis 2006 (MAP Kinase Signaling System...) : Phospho-ERK1/2 , Akt activity and expression of c-Myc were significantly induced by etoposide in a time dependent manner ; moreover, there was a weak effect on the expression of p53 protein
Wang et al., J Cell Physiol 2006 (Carcinoma, Hepatocellular...) : To study the relationship between ERK phosphorylation and cell growth inhibition, we used Cpd 5 as a tool to investigate ERK regulated c-Myc expression in Hep3B hepatoma cells ... We found that ERK phosphorylation caused by Cpd 5 induced c-Myc phosphorylation, but suppressed c-Myc expression at the mRNA and protein levels ... These data suggest that an increase in c-Myc phosphorylation in response to prolonged ERK phosphorylation negatively auto-regulates c-Myc gene expression, leading to the suppression of its target gene expression and cell cycle block
Hattrup et al., Breast Cancer Res 2006 (Breast Neoplasms...) : Additional changes were seen at the protein level, such as increased expression of c-Myc , heightened phosphorylation of AKT, and decreased activation of MEK1/2 and ERK1/2
Verykokakis et al., J Biol Chem 2007 : Thus Erf provides a direct link between the RAS/ERK signaling and the transcriptional regulation of c-Myc and suggests that RAS/ERK attenuation actively regulates cell fate
Pan et al., Cancer Biol Ther 2007 (Aneuploidy...) : We found that overexpression of gamma-catenin caused : ( 1 ) a reduction in E-cadherin and corresponding increase in vimentin levels concomitant with increased cell mobility and migration ; ( 2 ) enhancement in the levels of phosphorylated Akt and Erk in the presence of EGF and ( 3 ) an increase in PTTG and c-Myc protein levels, which are likely to accelerate chromosomal instability and uncontrolled proliferation, respectively, in the affected cells
Marampon et al., Mol Cancer Ther 2009 (Muscle Neoplasms...) : In this article, we investigate whether MEK/ERK inhibition, by the MEK/ERK inhibitor U0126, affects c-Myc protein level and growth of RMS tumor in an in vivo xenograft model
Duan et al., Dig Dis Sci 2010 (Bile Duct Neoplasms...) : Our results revealed that the specific MAPK-ERK cascade inhibitor, PD98059, significantly attenuated phosphorylation of c-Myc on Ser-62 and FasL upregulation in QBC-939 cells and these cells showed decreased cytotoxicity against Fas-sensitive Jurkat T cells
Lee et al., Nat Med 2010 (Intestinal Neoplasms...) : MyD88 ( myeloid differentiation primary response gene 88 ) -independent activation of ERK by epidermal growth factor (EGF) increased p-ERK and c-Myc and restored the multiple intestinal neoplasia ( Min ) phenotype in Apc ( min/+ ) /Myd88 ( -/- ) mice
Perera et al., Arthritis Res Ther 2010 (Inflammation) : ERK1/2 activation by mechanical forces induced SRY related protein-9 ( SOX-9 ), vascular endothelial cell growth factor ( VEGF ), and c-Myc mRNA expression and AC proliferation
Pan et al., Biochem Biophys Res Commun 2012 : Endoglin inhibits ERK induced c-Myc and cyclin D1 expression to impede endothelial cell proliferation ... We show that endoglin impedes cell growth through sustained inhibition of ERK induced c-Myc and cyclin D1 expression in a TGF-ß independent manner
Chappell et al., Genes Dev 2013 : In this study, we define a mechanism for this by showing that MYC/MAX complexes suppress ERK activity by transcriptionally regulating two members of the dual-specificity phosphatase ( DUSP ) family
Chuang et al., FEBS Lett 1994 : We also show that overexpression of ERK2 , encoding p42mapk, activates Myc , but not Elk-1