Gene interactions and pathways from curated databases and text-mining

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NAMPT — VEGFA

Text-mined interactions from Literome

Adya et al., Cardiovasc Res 2008 : Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways : novel insights into visfatin induced angiogenesis ... We therefore investigated the effect of visfatin on vascular endothelial growth factor ( VEGF ) and matrix metalloproteinases ( MMP-2, MMP-9 ) production and the potential signalling cascades ... In human umbilical vein endothelial cells ( HUVECs ), visfatin significantly and dose-dependently up-regulated gene expression and protein production of VEGF and MMPs and down-regulated expression of tissue inhibitors of MMPs ( TIMP-1 and TIMP-2 ) ... Interestingly, visfatin significantly up-regulated VEGF receptor 2 expression ... Our data provide the first evidence of visfatin induced endothelial VEGF and MMP production and activity
Xiao et al., Diabetes Metab Res Rev 2009 : Visfatin induced protein kinase B ( Akt ) phosphorylation and phosphoinositide 3 kinase (PI3K) inhibitors could suppress visfatin induced upregulation of DDAH2 and VEGF expressions
Park et al., Biochim Biophys Acta 2011 : Visfatin induced the expression of hypoxia-inducible factor 1a (HIF1a) and vascular endothelial growth factor ( VEGF ) in human endothelial cells ... The visfatin induced increase in VEGF expression was also eliminated by RNA interference mediated knockdown of the 70-kDa ribosomal protein S6 kinase ( p70S6K ), a downstream target of mTOR ... Taken together, these results indicate that mTOR signaling is involved in visfatin induced angiogenesis, and that this signaling leads to visfatin induced VEGF expression and nuclear translocation of ß-catenin