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NAMPT — VEGFA
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Adya et al., Cardiovasc Res 2008
:
Visfatin induces human endothelial
VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways : novel insights into visfatin induced angiogenesis ... We therefore investigated the
effect of
visfatin on
vascular endothelial growth factor ( VEGF ) and matrix metalloproteinases ( MMP-2, MMP-9 ) production and the potential signalling cascades ... In human umbilical vein endothelial cells ( HUVECs ),
visfatin significantly and dose-dependently
up-regulated gene expression and protein production of
VEGF and MMPs and down-regulated expression of tissue inhibitors of MMPs ( TIMP-1 and TIMP-2 ) ... Interestingly,
visfatin significantly
up-regulated VEGF receptor 2 expression ... Our data provide the first evidence of
visfatin induced endothelial
VEGF and MMP production and activity
Xiao et al., Diabetes Metab Res Rev 2009
:
Visfatin induced protein kinase B ( Akt ) phosphorylation and phosphoinositide 3 kinase (PI3K) inhibitors could suppress
visfatin induced upregulation of DDAH2 and
VEGF expressions
Park et al., Biochim Biophys Acta 2011
:
Visfatin induced the expression of hypoxia-inducible factor 1a (HIF1a) and
vascular endothelial growth factor ( VEGF ) in human endothelial cells ... The
visfatin induced increase in
VEGF expression was also eliminated by RNA interference mediated knockdown of the 70-kDa ribosomal protein S6 kinase ( p70S6K ), a downstream target of mTOR ... Taken together, these results indicate that mTOR signaling is involved in visfatin induced angiogenesis, and that this signaling leads to
visfatin induced
VEGF expression and nuclear translocation of ß-catenin