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NKD1 — WNT3
Text-mined interactions from Literome
Zhang et al., Mol Cell Biol 2007
:
Nkd inhibits
Wnt signaling by binding the intracellular protein Dishevelled ( Dsh )
Van Raay et al., Dev Biol 2007
:
Overexpression of
Nkd1 or Nkd2a
suppressed canonical
Wnt/beta-catenin signaling at multiple stages of early zebrafish development and also exacerbated the cyclopia and axial mesendoderm convergence and extension ( C & E ) defect in the non-canonical Wnt/PCP mutant silberblick ( slb/wnt11 ) ... Reducing
Nkd function using antisense morpholino oligonucleotides
resulted in increased expression of canonical
Wnt/beta-catenin target genes
Chan et al., Dev Biol 2008
:
Nkd is an intracellular protein that is composed of separable membrane- and nuclear-localization sequences ( NLS ) as well as a conserved EF-hand motif that binds the Wnt receptor associated scaffold protein Dishevelled ( Dsh ), but the mechanism by which
Nkd inhibits
Wnt signaling remains a mystery