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NOS1 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: NOS1 → TNF (increases)
  Evidence: Human chondrocytes exposed to TNF-alpha (1 ng/ml ) for 24 hours in ex vivo condition results in up-regulation of osteoarthritic - NOS (nitric oxide synthase ).

Text-mined interactions from Literome

Saura et al., J Mol Biol 1999 : We investigated the molecular mechanism for the synergistic induction of inducible nitric oxide synthase transcription by TNF-alpha and IFN-gamma
Er et al., J Cataract Refract Surg 1999 : These findings suggest a strong inhibitory effect of NOS inhibitors and corticosteroids on aqueous levels of TNF-alpha and NO and no inhibitory effect on IL-1 beta and IL-6 levels after cataract surgery
Cain et al., Crit Care Med 1999 (Cardiomyopathies...) : We hypothesized the following : a ) TNF-alpha and IL-1beta directly depress human myocardial function ; b ) together, TNF-alpha and IL-1beta act synergistically to depress human myocardial function ; and c ) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1beta by limiting proximal cytokine signaling or production of myocardial nitric oxide ( NO )
Wiest et al., J Clin Invest 1999 (Liver Cirrhosis, Experimental) : This TNF-alpha production was associated with elevated levels of tetrahydrobiopterin ( BH ( 4 ) ), a TNF-alpha stimulated cofactor and enhancer of eNOS derived NO biosynthesis and NOS activity in mesenteric vasculature
Zhu et al., Life Sci 1999 (Infarction, Middle Cerebral Artery...) : Nimodipine inhibited the Ca2+ independent NOS activity induced by lipopolysaccharide (LPS) + tumor necrosis factor alpha (TNF alpha) in mouse astroglial cells with an IC50 value of 0.036+/-0.003 mM and Ca2+ dependent NOS activity in mouse neurons with an IC50 value of 0.047+/-0.003 mM, but did not affect Ca2+ dependent NOS activity in BCECs
Akama et al., J Biol Chem 2000 : Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha) dependent , and involves a TNFalpha receptor associated factor- and NFkappaB inducing kinase dependent signaling mechanism
Däubener et al., Adv Exp Med Biol 1999 : We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase
Chung et al., Immunopharmacol Immunotoxicol 2000 : Protein kinase C independent activation of inducible nitric oxide synthase by tumor necrosis factor-alpha in TM4 Sertoli cells
Zhu et al., Life Sci 2000 : In addition, either 0.4 mM SNP/Vc and 800 U/ml TNFalpha alone or 0.4 mM SNP/Vc and 400 U/ml TNFalpha in combination significantly increased malondialdehyde ( MDA ) content, but nitric oxide synthase (NOS) activity was inhibited only by SNP/Vc and TNF in combination
Vann et al., J Biol Chem 2000 : Divergence in regulation of nitric-oxide synthase and its cofactor tetrahydrobiopterin by tumor necrosis factor-alpha
Yamaoka et al., Arch Dermatol Res 2000 : Ultraviolet B radiation downregulates inducible nitric oxide synthase expression induced by interferon-gamma or tumor necrosis factor-alpha in murine keratinocyte Pam 212 cells
Merial et al., Am J Physiol Cell Physiol 2000 : The characterization of the mechanisms responsible for the TNF-alpha effect on UCP-2 expression demonstrates an involvement of the TNF-alpha induced inducible ( i ) nitric oxide synthase (NOS) expression
Lee et al., Exp Neurol 2000 (Nerve Degeneration...) : These results suggest that : ( i ) TNF-alpha may function as an external signal initiating apoptosis in neurons and oligodendrocytes after spinal cord injury ; and ( ii ) TNF-alpha initiated apoptosis may be mediated in part by NO as produced by a NOS expressed in response to TNF-alpha
Combs et al., J Neurosci 2001 (Alzheimer Disease...) : beta-Amyloid stimulation of microglia and monocytes results in TNFalpha dependent expression of inducible nitric oxide synthase and neuronal apoptosis
González-Fernández et al., Atherosclerosis 2001 : Cerivastatin prevents tumor necrosis factor-alpha induced downregulation of endothelial nitric oxide synthase : role of endothelial cytosolic proteins
Ochoa et al., Ann Surg 2001 (Wounds and Injuries) : In contrast, nitric oxide synthase expression is induced by IL-1, tumor necrosis factor , and gamma interferon, a T-helper 1 cytokine profile
Paludan et al., Eur Cytokine Netw 2001 : Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1
Saxena et al., Arch Biochem Biophys 2001 (Disease Models, Animal...) : The ability of Japanese encephalitis virus ( JEV ) and JEV induced macrophage derived factor ( MDF ) to modulate nitric oxide synthase (NOS) activity in brain and tumor necrosis factor-alpha (TNF-alpha) and the possible antiviral role of NOS during JEV infection were investigated
Sekine et al., Endocrinology 2001 : This action of GH may be sufficient to suppress the synergistic induction of inducible nitric oxide synthase by interferon-gamma and TNFalpha , thereby preventing the cytotoxicity to beta-cells
Buck et al., EMBO J 2001 (Cachexia) : Here we show that tumor necrosis-alpha ( TNF-alpha ) treatment of primary mouse hepatocytes or TNF-alpha overexpression in a mouse model of cachexia induces oxidative stress, nitric oxide synthase (NOS) expression and phosphorylation of C/EBPbeta on Ser239, within the nuclear localization signal, thus inducing its nuclear export, which inhibits transcription from the albumin gene
Gayle et al., Brain Res Dev Brain Res 2002 (Encephalitis...) : Inhibition of the inducible form of nitric oxide synthase ( iNOS ) by L-NIL did not affect LPS toxicity, but increased the LPS induced levels of both TNF-alpha and IL-1beta
Thomas et al., Pancreas 2002 (Adenocarcinoma...) : Further, inhibition of nitric oxide ( NO ) synthase by L-NAME potentiated the TNF-alpha response, suggesting a protective role for endogenously produced NO in these two cell lines
Aljada et al., Metabolism 2002 : Tumor necrosis factor-alpha inhibits insulin induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells
Meng et al., Sheng Li Xue Bao 2001 : The NOS activity increased in the TNF-alpha and the TNF alpha+CCK-8 groups, while no significant difference was observed between the vehicle and the CCK-8 groups
Shin et al., FEBS Lett 2002 : Recombinant glucocorticoid induced tumor necrosis factor receptor ( rGITR ) induces NOS in murine macrophage
Ribeiro et al., J Urol 2002 (Cystitis...) : The induction of inducible nitric oxide synthase in the urothelium appears to depend on the synergistic effect of IL-1beta and TNF-alpha
Fecker et al., J Invest Dermatol 2002 (Breast Neoplasms...) : Inducible nitric oxide synthase is expressed in normal human melanocytes but not in melanoma cells in response to tumor necrosis factor-alpha , interferon-gamma, and lipopolysaccharide
Goodstone et al., Rheumatology (Oxford) 2002 : To compare the time- and concentration dependent effects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) on the induction of nitric oxide synthase (NOS) , the production of nitric oxide ( NO ) and the expression of aggrecan and hyaluronan ( HA ) in chondrocytes
Barsacchi et al., Mol Pharmacol 2003 : Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3 ' kinase, and Akt
Frost et al., Endocrinology 2003 : TNF alpha increased both nitric oxide synthase-II mRNA and protein, and the nitric oxide donor sodium nitroprusside decreased IGF-I mRNA levels in C2C12 cells
Gottstein et al., Br J Nutr 2003 (Arteriosclerosis) : In a macrophage cell line ( RAW 264.7 ) activated with interferon gamma plus lipopolysaccharide, both isoflavones were found to inhibit NO production and tumour necrosis factor alpha (TNF-alpha) secretion dose-dependently, but they did not affect mRNA levels for inducible nitric oxide synthase and cyclo-oxygenase-2
Shin et al., Exp Mol Med 2003 : Induction of nitric oxide synthase (NOS) by soluble glucocorticoid induced tumor necrosis factor receptor ( sGITR ) is modulated by IFN-gamma in murine macrophage
Fonseca et al., Eur J Immunol 2003 (Leishmaniasis, Cutaneous) : TNF-alpha mediates the induction of nitric oxide synthase in macrophages but not in neutrophils in experimental cutaneous leishmaniasis
Okamoto et al., Am J Physiol Lung Cell Mol Physiol 2004 (Acute Disease...) : Inhibition of NOS activity also suppressed production of TNF-alpha and macrophage inflammatory protein-2 by LPS stimulated mouse alveolar MH-S macrophages, and this was restored by NO
Paz et al., J Am Coll Cardiol 2003 (Disease Models, Animal...) : Effect of tumor necrosis factor-alpha on endothelial and inducible nitric oxide synthase messenger ribonucleic acid expression and nitric oxide synthesis in ischemic and nonischemic isolated rat heart
Sztrymf et al., Eur Respir J 2004 (Hepatopulmonary Syndrome...) : Since TNF-alpha is a potent activator of macrophagic inducible nitric oxide synthase (NOS) , the aim of this study was to investigate whether TNF-alpha inhibition prevented hepatopulmonary syndrome and hyperdynamic circulatory state in rats with cirrhosis
Candolfi et al., Neuroendocrinology 2004 : Here, we studied the effect of TNF-alpha on nitric oxide synthase (NOS) activity and expression in anterior pituitary cells from cycling and ovariectomized ( OVX ) rats, and the role of NO in TNF-alpha induced apoptosis of anterior pituitary cells ... TNF-alpha ( 50 ng/ml ) stimulated NOS activity in anterior pituitary cells from rats at both stages of the estrous cycle and in cells from OVX rats cultured either with or without E2
Mocellin et al., Clin Cancer Res 2004 (Melanoma...) : We investigated the role of endothelial nitric oxide synthase in determining the tumor-selective activity of TNF
Ortega-Gutiérrez et al., FASEB J 2005 (Multiple Sclerosis) : Additionally, in microglial cells, UCM707 decreases the production of the proinflammatory cytokines tumor necrosis factor (TNF)-alpha , interleukin (IL)-1beta, and IL-6 ; reduces nitric oxide levels and inducible nitric oxide synthase expression ; and is able to potentiate the action of a subeffective dose of the endocannabinoid anandamide
Makino et al., J Diabetes Complications 2005 (Diabetes Mellitus, Type 2...) : Serum TNF-alpha , sTNFR-I, and asymmetric dimethylarginine ( ADMA ), an endogenous inhibitor of NOS , in CD were significantly higher than in UD or NS
de Souza et al., Mol Cell Biochem 2006 : Both TNF-alpha and inosine increased nitrite accumulation and nitric oxide synthase activity ... Erythro-9- ( 2-hydroxy-3-nonyl ) adenine ( EHNA ), an adenosine deaminase inhibitor, abolished the TNF-alpha induced inosine increase, nitrite accumulation and nitric oxide synthase activity
Dekker et al., Blood 2006 : Protein levels for thrombomodulin, endothelial nitric oxide synthase , and plasminogen activator inhibitor type-1 are altered to atheroprotective levels, even in the presence of the inflammatory cytokine TNF-alpha
Costa et al., Br J Pharmacol 2006 (Hyperalgesia...) : AM404 completely prevented the overproduction of NO and the overexpression of nNOS , inhibited the increase in tumour necrosis factor alpha (TNFalpha) and enhanced the production of interleukin-10
Elahi et al., Exp Clin Transplant 2006 (Vascular Diseases) : The role of tumor necrosis factor-alpha in mediating pathophysiological activity of inducible nitric oxide synthase during transplant vasculopathy remains contentious
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma, TNF-alpha , IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Arai et al., Acta Otolaryngol 2008 : Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells
Choi et al., J Leukoc Biol 2008 : NOS was markedly inhibited by blocking antibodies to IFN-gamma and TNF-alpha , suggesting the key role of these lymphocyte cytokines in mediating NOS
Xu et al., Stem Cells 2009 : C/EBPbeta knockdown also inhibited the synergistic expression of CXCL1, inducible nitric oxide synthase , and CCL5 in response to concomitant IFNgamma and TNFalpha
Ramamoorthy et al., Am J Physiol Endocrinol Metab 2009 (Cachexia...) : In a mouse model of muscle wasting, TNF-alpha induces oxidative stress and nitric oxide synthase-2 (NOS2) and decreases myogenin, Jun-D, and creatinine kinase muscle isoform (CKM) expression
Nandi et al., Mol Cell Biochem 2010 (Enteritis...) : We evaluated the role of the pro-inflammatory cytokine TNF-alpha on nitric oxide synthase (NOS) expression in indomethacin induced jejunoileitis in rats
Tsou et al., J Cell Biochem 2010 : Integrin linked kinase is involved in TNF-alpha induced inducible nitric-oxide synthase expression in myoblasts
Zhang et al., Can J Physiol Pharmacol 2010 (Calcium Signaling...) : Interestingly, endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation, whereas neuronal NOS (nNOS) inhibits TNF-alpha production by reducing Ca2+ dependent ERK1/2 activity
Harada et al., Cell Death Differ 2010 (Disease Models, Animal...) : Tumor necrosis factor (TNF) induced activation of p38 MAPK and the production of inducible nitric oxide synthase were suppressed in ASK1-deficient Müller glial cells
Zhao et al., Mol Biol Rep 2012 (Glomerulonephritis) : Aldose reductase regulates TNF-a induced inducible nitric oxide synthase expression in human mesangial cells
Yoshioka et al., Mol Reprod Dev 2012 : TNF and IFNG stimulated NOS activity ( P? < ?0.05 ) and 1400W, a specific inhibitor of iNOS, reduced NO production stimulated by TNF and IFNG in LECs ( P? < ?0.05 )
Ning et al., PloS one 2013 (Inflammation...) : In addition, NaHS treatment prevented the increase of nitric oxide, Intercellular Adhesion Molecule 1 ( ICAM-1 ) and interleukin (IL)-6 production and inducible nitric oxide synthase activation induced by TNF-a
Yamada et al., Biochem Biophys Res Commun 1993 : Nitric oxide and nitric oxide synthase mRNA induction in mouse islet cells by interferon-gamma plus tumor necrosis factor-alpha
Koide et al., Hypertension 1994 : These findings suggest that interferon gamma directly induces the expression of the inducible nitric oxide synthase gene, whereas tumor necrosis factor-alpha and interleukin-1 beta induce it, at least in part, via the induction of intermediary protein ( s ), and that transforming growth factor-beta 1 inhibits cytokine induced nitric oxide production by blocking the posttranscriptional synthesis of inducible nitric oxide synthase
Marumo et al., Jpn J Pharmacol 1993 : Dexamethasone inhibits nitric oxide synthase mRNA induction by interleukin-1 alpha and tumor necrosis factor-alpha in vascular smooth muscle cells
Lin et al., Infect Immun 1994 : In this study, we determine whether tumor necrosis factor alpha (TNF-alpha) produced by activated bone marrow derived macrophages ( BMM ) is involved in the induction of the inducible NO synthase gene ( mac-NOS ) for NO-dependent amebicidal activity
Florquin et al., J Exp Med 1994 (Shock, Septic) : In vitro experiments indicated that NO synthase (NOS) inhibition by N-nitro-L-arginine methyl ester ( L-NAME ) enhanced IFN-gamma and TNF production by splenocytes in response to SEB
Murata et al., Int J Cancer 1994 (Colonic Neoplasms) : NOS activity was increased by TNF-alpha and IFN-gamma, and significantly reduced by tumor-cell conditioned medium
Duval et al., Arch Biochem Biophys 1995 : Dithiothreitol, a thiol antioxidant, reduced TNF alpha induction of NOS ... Nitric oxide synthase (NOS) induction by tumor necrosis factor-alpha (TNF alpha) is synergized by interferon-gamma, and both NOS activity and gene expression are maximal by 10 h and maintained through 24 h. Glutathione depletion by diethylmaleate, which conjugates reduced glutathione, 1,3-bis ( chloroethyl ) -1-nitrosourea ( BCNU ), a glutathione reductase inhibitor, or buthionine sulfoxamine, a glutathione synthesis inhibitor, abolishes or reduces NOS induction in TNF alpha treated hepatocytes, whereas N-acetylcysteine has little effect
Renier et al., Arterioscler Thromb Vasc Biol 1995 : Protein synthesis was required for the induction of NOS mRNA, and a TNF-alpha mediated effect of LPL on NOS gene expression and NO production was observed
Veszelovsky et al., Cancer Chemother Pharmacol 1995 : Using previously published data, we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA, the enhancement of NOS activity in response to TNF , and the elevation of plasma nitrate in response to NO production
Maciejewski et al., J Clin Invest 1995 : IFN-gamma and TNF-alpha , potent inhibitors of hematopoiesis, induce nitric oxide synthase (NOS) in various cell types
Tsuji et al., Am J Pathol 1995 (Granuloma...) : Thus, interleukin-1 alpha and inducible nitric oxide synthase were induced mostly in the cells accumulated around the beads and also in some bronchiolar epithelial cells during the early phase ( 1 to 3 days ), whereas tumor necrosis factor-alpha was induced in the cells around the beads at the later resolution phase ( 3 to 7 days )
Adamson et al., Toxicol Appl Pharmacol 1993 : In combination, TNF alpha and IFN-gamma markedly increased NOS activity beyond that expected for a merely additive effect
Xie et al., Am Rev Respir Dis 1993 : Tumor necrosis factor alpha (TNF alpha) increases nitric oxide ( NO ) synthase in vascular endothelium, but it inhibits endothelium dependent relaxation ( EDR ) of vascular smooth muscle
Thiemermann et al., Br J Pharmacol 1993 (Shock, Septic) : 1. This study investigates the role of tumour necrosis factor (TNF) in the induction of nitric oxide synthase (NOS) by bacterial endotoxin ( lipopolysaccharide ; LPS ) in a rat model of endotoxin shock
Dunger et al., Diabetes 1996 : Used alone or in combination, TNF and IFN significantly enhanced the activity of inducible nitric oxide synthase as determined by measuring the conversion of 14C labeled arginine to 14C labeled citrulline and nitric oxide
Buck et al., EMBO J 1996 (Cachexia...) : In a murine model of muscle wasting, tumor necrosis factor alpha (TNF alpha) induces oxidative stress and nitric oxide synthase (NOS) in skeletal muscle, leading to decreased myosin creatinine phosphokinase (MCK) expression and binding activities
Geng et al., Cancer Res 1996 (Leukemia, Erythroblastic, Acute) : Apoptotic death of human leukemic cells induced by vascular cells expressing nitric oxide synthase in response to gamma-interferon and tumor necrosis factor-alpha
Duval et al., Mol Pharmacol 1996 : Induction of hepatic nitric oxide synthase (NOS) by tumor necrosis factor-alpha (TNF alpha) , interleukin-1 beta (IL-1 beta), interferon-gamma (IFN gamma), interleukin-6 (IL-6), and lipopolysaccharide was assessed as activity and immunoreactive protein ... NOS induction by TNF alpha was dose dependent from concentrations of 0.06 to 60 nM and was increased 2-3-fold by IFN gamma
Manfield et al., Inflamm Res 1996 : Here we show that in cultured bovine chondrocytes and explants of human osteoarthritic cartilage both nitric oxide synthase and cyclooxygenase activities were induced by the inflammatory mediators, lipopolysaccharide, and interleukin-1 beta or tumor necrosis factor-alpha
Simper et al., Cardiovasc Res 1995 (Shock, Septic) : Experimental and clinical evidence suggests that tumour necrosis factor-alpha (TNF) induces the expression of vascular nitric oxide ( NO ) synthase within hours and that NO released from smooth muscle cells could be involved in the pathogenesis of septic shock
Romero et al., Am J Physiol 1996 : Roles of IL-1 and TNF-alpha in endotoxin induced activation of nitric oxide synthase in cultured rat brain cells ... To determine whether LPS induction of NOS in brain cells is mediated by IL-1 or TNF-alpha , acting alone or in concert, the effects of IL-1-receptor antagonist (IL-1Ra) and of TNF-soluble receptor ( TNFsRp55 ), presented individually and in combination, on LPS induced NOS activity were tested ... The results indicate that LPS induction of NOS activity in brain cells is mediated in part by both IL-1 beta and TNF-alpha
Zwaveling et al., Crit Care Med 1996 (Neoplasms...) : The hypothesis that in humans, TNF-alpha induces vasodilation and shock through activation of inducible nitric-oxide synthase and subsequent formation of excessive quantities of nitric oxide is not substantiated by our results
Miller et al., Am J Physiol 1997 : Genistein inhibited tumor necrosis factor-alpha (TNF-alpha) stimulated induction of NOS activity and NOS protein in a dose dependent manner ... Genistein also impaired TNF-alpha induced NOS mRNA accumulation, suggesting protein tyrosine kinase regulation of NOS induction occurred at the level of transcription-translation
Low et al., Biochem Mol Biol Int 1997 : NOS activity was stimulated by exposure to interferon-gamma (IFN-gamma) and could be further stimulated by tumour necrosis factor-alpha (TNF-alpha) and epidermal growth factor (EGF) although neither was affective alone
Ogura et al., Biochem Biophys Res Commun 1997 (Neuroblastoma) : TNF-alpha mediates inducible nitric oxide synthase expression in human neuroblastoma cell line by cisplatin
Obregón et al., Eur J Neurosci 1997 (Brain Neoplasms...) : The isoform of the nitric oxide synthase induced in human neuroblastoma cells by TNF-alpha treatment was identified enzymatically as isoform II by Western blotting and by the polymerase chain reaction
Gansauge et al., FEBS Lett 1997 : Induction of inducible nitric oxide synthase by tumor necrosis factor-alpha , interferon-gamma and interleukin-1beta inhibited cell proliferation and led to a G1 arrest
Amore et al., J Am Soc Nephrol 1997 : This study suggests that dialytic `` acetate intolerance '' can be induced by the activation , through cAMP and tumor necrosis factor release, of NOS
Kuemmerle et al., Am J Physiol 1998 : After 48 h, NOS II activity, measured as L- [ 3H ] citrulline production, was increased 24.3 +/- 6.9 pmol.min-1.mg protein-1 by 1 nM IL-1 beta and 3.2 +/- 1.1 pmol.min-1.mg protein-1 by 1 nM TNF-alpha , and increased synergistically by a combination of the two ( 51.8 +/- 7.3 pmol.min-1.mg protein-1 )
Hoffmann et al., Int Arch Allergy Immunol 1998 : Single stimulation of smooth muscle cells with either neopterin or tumor necrosis factor-alpha caused inducible nitric oxide synthase gene expression and nitric oxide production
Hoffmann et al., Eur J Pharmacol 1998 : We show that G-CSF suppresses interferon-gamma/tumor necrosis factor-alpha (TNF-alpha) induced inducible nitric oxide synthase gene expression detected as inducible nitric oxide synthase cDNA ( cDNA concentration was 633 +/- 38 amol/microg total RNA following 24 h incubation with 100 U/ml interferon-gamma/500 U/ml TNF-alpha, and 440 +/- 14 amol/microg total RNA following 24 h incubation with 250 U/ml G-CSF +/- 100 U/ml interferon-gamma/500 U/ml TNF-alpha, respectively )
Yanagisawa et al., Toxicol Appl Pharmacol 1998 (Acute Kidney Injury...) : To elucidate the mechanisms underlying the development of HgCl2 induced acute renal failure ( ARF ), we examined the expression of endothelin (ET)-1, endothelial ( e ) nitric oxide synthase (NOS) and inducible ( i) NOS , and a role of angiotensin II (ANG II) and tumor necrosis factor (TNF) in glomeruli and cortices from rats at 20 h after exposure of HgCl2. Prepro-ET-1 and iNOS mRNA were significantly increased in glomeruli and cortices from rats with HgCl2 induced ARF
Ookawauchi et al., J Hepatol 1998 : The effect of tumor necrosis factor-alpha and interferon-gamma on L-arginine transport, mRNA expression of cationic amino acid transporter and inducible nitric oxide synthase , and nitric oxide production of stellate cells was assessed ... In transformed hepatic stellate cells, tumor necrosis factor-alpha and interferon-gamma have a crucial role in nitric oxide production, and extracellular L-arginine transport and inducible nitric oxide synthase expression are regulated in a differential cytokine-specific manner