Adachi et al., Hepatology 2005
(Liver Cirrhosis) :
In conclusion, NAD ( P ) H oxidase is expressed in HSCs and produces ROS via activation of NAD ( P ) H oxidase in response to PDGF-BB Bondi et al., J Am Soc Nephrol 2010
:
The Smad3 inhibitor SIS3 reduced NADPH oxidase activity, Nox4 expression, and blocked alpha-SMA and Fn-ED-A, indicating that stimulation of myofibroblast activation by ROS is downstream of Smad3