Gene interactions and pathways from curated databases and text-mining

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CDKN1A — NRAS

Text-mined interactions from Literome

VaquƩ et al., J Biol Chem 2005 (Leukemia...) : c-Myc antagonized the induction of p21Cip1 mediated by oncogenic H-, K-, and N-Ras and by constitutively activated Raf and ERK2
Haferkamp et al., Aging 2009 (Retinoblastoma) : Furthermore, we show that although both p16(INK4a) and p21 ( Waf1 ) are upregulated in response to N-RAS ( Q61K ), the activities of these CDK inhibitors are clearly distinct and only the loss of p16(INK4a) weakens senescence