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MAPK12 — P2RX7

Text-mined interactions from Literome

Michel et al., Br J Pharmacol 2006 (Calcium Signaling) : In this study we have further studied the effect of MAPK inhibitors on recombinant and native P2X(7) receptors ... Overall, the data cast doubt on a general role of MAPK in mediating P2X(7) receptor mediated changes in cellular permeability
Barbieri et al., Neurochem Int 2008 (Encephalitis...) : In this study, we investigated whether P2X7 stimulation on cultured cortical astrocytes promoted a differential activation of mitogen activated protein kinases ( MAPKs ), and whether the second messenger arachidonic acid ( AA ), which is also a key modulator of neuroinflammation, affected the P2X7 mediated MAPK phosphorylation
Bianco et al., Purinergic Signal 2009 : Furthermore, P2X(7) receptor activation promptly induces p38 mitogen activated protein kinase ( MAPK ) phosphorylation in cortical but not in hippocampal astrocytes
Faria et al., Naunyn Schmiedebergs Arch Pharmacol 2010 : Our results show that PKC, MAPK , PI3K, and cytoskeletal components are involved in P2X(7) receptor large-channel formation in 2BH4 cells and peritoneal macrophages
Kawano et al., Biochem Biophys Res Commun 2012 : P2X4-knockdown cells, established by transfecting RAW264.7 cells with two short hairpin RNAs ( shRNAs ) targeting P2X4 receptor, showed a decrease of the initial peak of intracellular Ca ( 2+ ) after treatment with ATP, though pore formation and the P2X7 mediated activation of ERK1/2 and p38 MAPK were not affected