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NEUROD1 — PAX6

Text-mined interactions from Literome

Marsich et al., Biochem J 2003 : The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2 ... Furthermore, by transient transfection experiments we demonstrated that the expression of basic helix-loop-helix transcription factor NeuroD/BETA2 can induce activation of the PAX6 promoter in the NIH-3T3 cell line ... Thus we show that NeuroD/BETA2 is involved in the activation of the expression of PAX6 through E boxes in the PAX6 promoter localized in a 1.1 kb sequence within the 4.6 kb untranslated region upstream of exon 0
Manuel et al., Development 2007 : Previous loss-of-function studies have indicated that Pax6 is required for normal cortical progenitor proliferation, neuronal differentiation , cortical lamination and cortical arealization, but whether and how its level of expression affects its function is unclear
Shimizu et al., Biol Pharm Bull 2009 : Pax6-5a promotes neuronal differentiation of murine embryonic stem cells
Zhang et al., J Cell Physiol 2012 : Ectopic expression of INSM1 directly induces insulin, Pax6 , and Nkx6.1 expression, whereas Pdx-1 and NeuroD1 were slightly suppressed by INSM1