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PDB1 — PLD4

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Kötter et al., Biochim Biophys Acta 2000 : Basal PLD activity was strongly ( 10-fold ) increased by 4beta-phorbol-12beta,13alpha-dibutyrate (PDB) ( EC ( 50 ) : 56 nM ), an effect which was inhibited by Ro 31-8220 ( 0.1-1 microM ), an inhibitor of protein kinase C ( PKC ), and by brefeldin A ( 10-100 microg/ml ), an inhibitor of ADP ribosylating factor ( ARF ) activation ... Pretreatment of the cultures with Clostridium difficile toxin B-10463 ( 0.1-1 ng/ml ), which inactivates small G proteins of the Rho family, led to a breakdown of the astroglial cytoskeleton ; concomitantly, PLD activation by PDB was reduced by up to 50 %
Klein et al., J Neurochem 1998 : Activation of PLD by 4beta-phorbol 12beta,13alpha-dibutyrate (PDB) was independent of age, whereas the effect of aluminum fluoride ( AlF4- ) increased to a plateau within the first week
Lindmar et al., Biochem Pharmacol 1998 (Second Messenger Systems) : Fluoride and 4beta-phorbol-12beta,13alpha-dibutyrate (PDB) , in contrast to 4beta-phorbol-13alpha-acetate ( PAc ), activated PLD , catalyzing the formation of [ 3H ] -phosphatidylethanol ( [ 3H ] -PETH ), [ 3H ] -phosphatidic acid ( [ 3H ] -PA ), choline and sn-1,2-diacylglycerol ( DAG ) ... In contrast, PDB mediated PLD activity was blocked by Ro 31-8220 and was resistant to extracellular Ca2+-depletion and desensitized within ca. 15 min. PDB markedly potentiated the fluoride evoked generation of [ 3H ] -phosphatidylethanol and of choline, but inhibited the formation of [ 3H ] -inositol phosphates ( [ 3H]-IP(1-3) )