Gene interactions and pathways from curated databases and text-mining

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AKT1 — PDLIM7

Text-mined interactions from Literome

Dawson et al., J Biol Chem 2003 (Cell Transformation, Viral) : LMP1 was found to stimulate PI3K activity inducing phosphorylation and subsequent activation of Akt , a downstream target of PI3K responsible for promoting cell survival
Mainou et al., Oncogene 2005 (Cell Transformation, Neoplastic) : The activation of the PI3K pathway in Rat-1 cells by LMP1 and LMP1-CTAR1 in transformed cells resulted in phosphorylated Akt and phosphorylated glycogen synthase kinase 3beta ... Similar studies in human fibroblasts confirmed that LMP1-CTAR1 also mediates aberrant growth, phosphorylation of Akt , and decreased levels of p27
Shair et al., Cancer Res 2008 : However, constitutive activation of Akt alone did not alter cell growth, suggesting that both PI3K/Akt and NF-kappaB activation are required by LMP1
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production ... Whereas Src kinases are often required for Syk activation, we show here that PI3K/Akt activation and autocrine IL-10 production by NGFR-LMP1 involves the Src family kinase Fyn