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AKT1 — PDLIM7
Text-mined interactions from Literome
Dawson et al., J Biol Chem 2003
(Cell Transformation, Viral) :
LMP1 was found to stimulate PI3K activity
inducing phosphorylation and subsequent activation of
Akt , a downstream target of PI3K responsible for promoting cell survival
Mainou et al., Oncogene 2005
(Cell Transformation, Neoplastic) :
The activation of the PI3K pathway in Rat-1 cells by
LMP1 and LMP1-CTAR1 in transformed cells
resulted in phosphorylated
Akt and phosphorylated glycogen synthase kinase 3beta ... Similar studies in human fibroblasts confirmed that
LMP1-CTAR1 also
mediates aberrant growth, phosphorylation of
Akt , and decreased levels of p27
Shair et al., Cancer Res 2008
:
However, constitutive activation of Akt alone did not alter cell growth, suggesting that both
PI3K/Akt and NF-kappaB activation are
required by
LMP1
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that
NGFR-LMP1 utilizes Syk to
activate PI3K/Akt signaling and induce IL-10 production ... Whereas Src kinases are often required for Syk activation, we show here that
PI3K/Akt activation and autocrine IL-10 production by
NGFR-LMP1 involves the Src family kinase Fyn